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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 61 - 70 of 207728 results
  1. Refinement of lead compounds to modulate water permeability through AQP4

    SBC: AEROMICS, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): Cerebral edema (and its counterpart in the spinal cord) is a major contributor to the damage caused by stroke, traumatic brain injury, traumatic spinal-cord injury, and bacterial meningitis. Stroke alone is the third leading cause of death in the USA and the leading cause of disability. Unfortunately, few treatment options are available for cerebral and spinal- ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  2. A Fast-Response Atmospheric Turbulence (FRAT) Probe with Gas-Sampling Ducts

    SBC: AEROPROBE CORPORATION            Topic: S1

    Aeroprobe proposes to design, construct and test an air-data probe with substantially higher frequency response than currently available. This fast-response atmospheric turbulence probe (FRAT probe) will be able to sample ambient air, and measure CO2 and other gases. Phase I work demonstrated that with a proper design of the probe nose, ingestion holes for gas sampling do not interfere with port ...

    SBIR Phase II 2010 National Aeronautics and Space Administration
  3. Accelerated Discovery and Development of New Pain Therapeutics

    SBC: AESTUS THERAPEUTICS, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Neuropathic pain is a common complication of cancer, diabetes mellitus, viral infections, and other causes. Although physicians currently employ a variety of treatments to manage moderate to severe neuropathic pain, including non-steroidal anti-inflammatory drugs, opioids, tricyclic antidepressants, anti- seizure medications, serotonin-norepinephrine reupta ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  4. Localized Growth Factor Therapy for Surgical Hernia Repair

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Over 700,000 surgical hernia repairs are performed each year in the United States and despite recent advances, a significant rate of recurrence persists. The incorporation of biocompatible mesh to strengthen the abdominal fascia has largely replaced high-tension suturing techniques in hernia repair. Currently, the preferred biomaterials include durable syntheti ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  5. Development of an adipose-derived stem cell isolation matrix

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Mesenchymal stem cells (MSCs) are an adult stem cell population, typically isolated from bone marrow aspirates, and are capable of self-renewal, expansion in culture, and differentiation into adipocytes, chondrocytes, and osteoblasts. These cells are being explored for use in tissue engineering applications, such as spinal fusions, bone defect repairs, and cart ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  6. Recombinant expression of a biomaterial-targeting BMP-2 containing a peptide tag

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): The emergence of biological therapeutics, including cells, peptides, and proteins, has allowed medical science to address a number of unmet clinical needs. Often these agents are extremely potent, specifically activating endogenous signaling cascades to promote well-characterized biochemical and physiological responses. For example, bone morphogenetic protein-2 ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a method to multiplex ChIP-SEQ and ChIP-chip experiments

    SBC: AFFOMIX, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): The immediate objective of our research is to generate a method that will enable researchers to multiplex Chromatin ImmunoPreciptation-Sequencing (ChIP-Seq) analysis in a single Next generation DNA sequencing run. In the to-be-developed method: i) a set of antibodies directed against specific DNA-binding proteins are uniquely bar-coded with a DNA 'ZipCode;' ii) ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  8. High-throughput screening and identification of scFv antibodies against glycosyla

    SBC: AFFOMIX, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): The specific goal of this proposal is to develop a high-throughput method to identify scFv antibodies that recognize post-translationally modified proteins. We propose to complete a proof-of-concept for a new type of affinity screening process based on emulsion, secretion, and capture, which we term ESCape . In the proposed phage ESCape method, E. coli transfo ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  9. A bifunctional antibody screening system for both phage display and yeast two-hyb

    SBC: AFFOMIX, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): This is a proposal to establish a proof-of-principle for a vector system to isolate high-affinty antibodies through selective rounds in both yeast and Escherichia coli. Antibodies have quickly become extremely useful as therapeutic medicines to treat a wide-variety of disorders. We propose to develop a means of making the discovery of immunotherapeutics faster ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  10. Water Toxicity Detection using Genetically Engineered Yeast

    SBC: AGAVE BIOSYSTEMS INC.            Topic: Army08174

    The rapid evaluation of drinking water toxicity in the field is a necessity for the safety of our soldiers. To achieve field portability and sensitive screening for identification of toxic industrial chemicals (TICs) a handheld device that is biologically-based and easy to use with components that remain viable for 6 months would be ideal. In Phase I, Agave BioSystems proposed to develop an accura ...

    SBIR Phase II 2010 Department of DefenseArmy
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