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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of a TRPA Antagonist Opioid Sparing Analgesic for Chronic Pain

    SBC: ALGOMEDIX, INC.            Topic: NIDA

    Chronic pain affects over million Americans While opioids are recognized as the most effective drugs for the relief of pain the US is now suffering from an epidemic of abuse addiction and accidental overdose deaths resulting from prescription opioids The goal of this proposal is develop a novel non opioid analgesic drug devoid of addiction and abuse liabilities and to define its opioid spa ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Electrochemical Paper-Based Analytical Devices for Metal Determination

    SBC: Access Sensor Technologies LLC            Topic: NIEHS

    Project Summary The goal of this project is to develop a new sampling and analysis system combining two new technologiesA lightweight ultrasonic sampler will be paired with an electrochemical paper based analytical deviceePADfor measurement of metals in airborne particulate matterPMExposure to particulate matterPMair pollution ranks as theth leading risk factor for human morbidity and mortality wo ...

    SBIR Phase II 2017 Department of Health and Human Services
  3. Clinical Study of an Extended Patency Dialysis Access Graft

    SBC: HEALIONICS CORPORATION            Topic: 300

    Clinical Study of an Extended Patency Dialysis Access Graft PROJECT SUMMARY Objective The goals of this PAR Clinical Studies Fast Track SBIR proposal are to move a novel hemodialysis access graft design to k submission and upon k clearance conduct a patient clinical study to demonstrate improved performance compared to current synthetic grafts which have high rate of clot ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Chemo-enzymatic synthesis of nucleotide sugar libraries and therapy-relevant derivatives

    SBC: CHEMILY, LLC            Topic: 300

    Glycans and glycoconjugates are widespread in nature and play pivotal roles in cell cell recognitioncell differentiationand immunological responsesMost glycans and glycosylation reactions require nucleotide sugars as their essential building blocksThereforethe commercial availability of nucleotide sugars will determine future opportunities for carbohydrate based innovationsjust as the availability ...

    SBIR Phase I 2017 Department of Health and Human Services
  5. A high throughput sample preparation platform for genomic and epigenetic analysis

    SBC: Matchstick Technologies Inc.            Topic: 200

    Several types of cancers e g pancreatic and brain malignancies remain extremely lethal despite the introduction of chemotherapy more than years ago The hallmark of all cancers are somatic mutations which cannot be corrected In sharp contrast epigenetic changes essential contributors to tumorigenesis are pharmacologically reversible The ability to remedy detrimental epigenetic alteratio ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Kinetic Phenotype Discovery Informatics for Neurological Diseases

    SBC: DRVISION TECHNOLOGIES LLC            Topic: 101

    Project Summary Neurological disorders significantly outnumber diseases in other therapeutic areas and are growing in incidence faster than any other disease classesHoweverthe pharmaceutical industry has been unsuccessful in coming up with effective drugsA big factor in these failures has been a lack of adequate model systems for fundamental disease understanding affecting both diagnosis and treat ...

    SBIR Phase II 2017 Department of Health and Human Services
  7. Phase 1 Clinical Evaluation of NP10679, a GluN2B Selective,Context-Dependent NMDA Receptor Inhibitor for Subarachnoid Hemorrhage

    SBC: NEUROP, INC.            Topic: 102

    Abstract Subarachnoid hemorrhageSAHremains a serious source of neurological morbiditywith approximatelycases reported in the US each yearDespite advances in treating the initial and subsequent bleedspost surgical clipping of the aneurysm is associated with a significant risk of delayed cerebral ischemiaDCIThese events typically occur within the firstdays after aneurysmal rupture and DCI remains th ...

    SBIR Phase II 2017 Department of Health and Human Services
  8. Micro Patterned Intraocular Lens Membrane for Reducing Incidence of PCO

    SBC: CLEARSIGHT, LLC            Topic: N

    AbstractThe exponential increase of diabetics and the elderly in the U Shas more than tripled the number of cataract surgeries performed in just two decadesAs many as half of these surgeries will lead to posterior capsular opacificationPCOwhich requires follow up Nd YAG laser capsulotomy surgeryWithout this additional procedurepatients can suffer permanent vision loss and disabilityIn many countri ...

    SBIR Phase II 2017 Department of Health and Human Services
  9. Advanced therapeutic for Parkinson's Disease

    SBC: INHIBIKASE THERAPEUTICS            Topic: 105

    Parkinson s DiseasePDis a progressive neurodegenerative disorder that affectsmillion patient in the U Sannually andtomillion people worldwidePD is characterized by disorders of movementwhich are caused by the progressive loss of dopamine neurons in the substantia nigra pars compactaSNpcand autonomic dysfunctionanxietydepressionsleep disorders and cognitive impairment that are due to the degenerati ...

    SBIR Phase II 2017 Department of Health and Human Services
  10. Personal Mercury Monitor for Exposure Measurements

    SBC: 2B TECHNOLOGIES, INC.            Topic: 113

    Personal Mercury Monitor for Exposure Measurements Project Summary Abstract Workers in the oil and natural gas industry are vulnerable to exposure to toxic mercury Hg vapor as a result of routine inspection and maintenance of equipment such as compressors and other process equipment that concentrate species of low volatility over time Exposure of workers to mercury is of concern in many other ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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