List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Nanostructured Ultrafiltration Membranes for Biological Applications

    SBC: SYNKERA TECHNOLOGIES INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): This multi-phase SBIR project targets a significant problem within the mission of the National Institute of General Medical Sciences: rapid size-based purification and separation of macromolecules, including proteins, nucleic acids and polysaccharides. The main objective is to develop novel ultrafiltration membranes with unprecedented sharp and controllable mol ...

    SBIR Phase II 2010 Department of Health and Human Services
  2. Generation of HIV resistant cells from protein transduced hematopoetic stem cell

    SBC: TAIGA BIOTECHNOLOGIES INC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Using a method of retroviral gene transduction we have been able to generate conditionally immortalized long-term hematopoietic stem cell lines from primary mouse blood stem cells. Phase I of this project included applying this technology to generate human cell lines. In addition, the project included testing a non-viral method to generate the stem cell lines f ...

    SBIR Phase II 2010 Department of Health and Human Services
  3. Large-scale generation of human red blood cells for transfusion therapy

    SBC: TAIGA BIOTECHNOLOGIES INC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Using a method of retroviral gene transduction we have been able to generate conditionally immortalized long-term hematopoietic stem cell lines from primary human cord blood stem cells. Phase I of this project includes applying newly discovered non- viral technology to generate human cell lines and the subsequent differentiation of those cells into human red bl ...

    SBIR Phase I 2010 Department of Health and Human Services
  4. Molecular based strategies to generate protective immune responses to HIV-1

    SBC: TAIGA BIOTECHNOLOGIES INC            Topic: NIAID

    DESCRIPTION (provided by applicant): Using a new approach to adjuvant design we have identified a molecular based adjuvant that enhances immune response by several criteria including, an earlier response, a stronger response to more parts of the vaccine, and the ability to respond to very small amounts of vaccine. Phase I of this project involves applying the same technology to HIV-1 antigens. Pha ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. Multiplex Diagnostic for Enteric Category B Pathogens and Intestinal Biomarkers

    SBC: TECHLAB, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Our goal is development of a multiplex immunodiagnostic panel specific for Giardia, Cryptosporidium, E. histolytica, and shiga toxin-producing Shigella and E. coli detection in stool. Additional effort will quantify the fecal biomarkers lactoferrin and hemoglobin, indicators of intestinal inflammation and hemorrhage. The full multiplex panel will provide rapid ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Treatment of Canine Diabetic Cataracts

    SBC: Therapeutic Vision, Inc.            Topic: NEI

    DESCRIPTION (provided by applicant): Diabetes mellitus (DM) in dogs is characterized by a rapid onset of bilateral cataracts that result in vision loss. Over 400,000 dogs annually develop cataracts that results in vision loss and currently the only medical treatment for these dogs is cataract surgery between 3,500-6,000. We have developed an alternative, nonsurgical medical treatment that is comp ...

    SBIR Phase II 2010 Department of Health and Human Services
  7. IHC Test for BRCA1 Hereditary Ovarian Cancer

    SBC: TISSUE GENETICS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): This is a Fast-Track proposal to develop a tissue-based genetic test for BRCA1 hereditary ovarian cancer. Ten percent of unselected US ovarian cancers are BRCA1 hereditary cancers with truncating mutations in the BRCA1 gene. It is important to know which ovarian cancer patients have BRCA1 hereditary ovarian cancer because BRCA1 patients have an increased risk o ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. Beating-Heart Surgery for Heart Valve Replacement

    SBC: VALVEXCHANGE, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Each year, over 115,000 patients in the US need to have their diseased heart valves replaced with artificial devices. Although bioprosthetic valves are considered ideal, they wear out in about 15 years and are thus used primarily in the elderly who are not expected to outlive the valve. Younger patients receive mechanical valves that are more durable, but requi ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. Production of OspA in rice for the control of Lyme disease

    SBC: VENTRIA BIOSCIENCE            Topic: NIAID

    DESCRIPTION (provided by applicant): A vaccine for humans against Lyme disease caused by B. burgdorferi is currently not available due to poor market acceptance and safety concerns of an injectable vaccine based on outer surface protein A (OspA). An alternative approach to protecting humans from Lyme disease is to vaccinate the disease reservoirs to reduce or eliminate B. burgdorferi from vector t ...

    SBIR Phase II 2010 Department of Health and Human Services
  10. Lactoferrin for the prevention of antibiotic-associated diarrhea in adult

    SBC: VENTRIA BIOSCIENCE            Topic: NIA

    DESCRIPTION (provided by applicant): Patients treated with antibiotics frequently develop diarrhea. In developed countries, adults, particularly the elderly, experience a higher death rate due to diarrhea than children. Results from in vitro and preliminary in vivo studies lead us to hypothesize that oral administration of recombinant human lactoferrin as a medical food might be able to prevent an ...

    SBIR Phase I 2010 Department of Health and Human Services

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government