Award Data

PROJECT SUMMARY ABSTRACT Public Health Problem In the U Speople agedyears and older are living with HIV infectionwith approximatelyothers infected but undiagnosedFor most HIV positive individualsavailable treatments can only control HIV infection and delay progression to AIDSHAART has substantial side effects and fails to prevent at leastof patients from developing HIVassociated neurocognitive dis ...

PROJECT SUMMARY ABSTRACTCairnSurgical LLCa Dartmouth spin off companywill optimize and test multi site clinical feasibility of a new image guided intervention devicethe Breast Cancer LocatorBCLin breast conserving surgeryBCStoieliminate wire localizationa moderately effectivesomewhat costly and certainly inconvenient procedure for patients and surgeonsand concomitantly toiireduce positive margin r ...

The very forces critical to creating the three dimensional structure of proteins are alsoresponsible for unwanted and often dangerous protein aggregates in proteinbased therapeuticsProtein aggregation occurs at every stage in the pipelinefrom developmentformulationandmanufacturing to shippingstorage and point of useThe FDA advised in itsGuidance forIndustry that ``It is critical for manufacturers ...

Project SummaryAbstract The goal of this project is to develop a novel device for respiratory therapy that uses interactive gaming and music to encourage patient complianceIn order to maintain pulmonary healthmany post operative surgery patients as well as people with quadriplegia and other spinal cord injurieshigh level motor neuron diseases such as amyotrophic lateral sclerosisALSand multiple sc ...

OtoNexus is developing the world s first medical device to provide definitiveobjective diagnostic data for the rapid and accurate diagnose middle ear infectionscalled Otitis Mediain children and adultsThis FAST TRACK proposal addresses the clinical difficulty of determining the nature of fluid behind the tympanic membraneear drumin acute infection of the middle earAcute Otitis MediaAOMClinical stu ...

Project SummaryAbstract Understanding brain function is key to improving health care and advancing a number of scientific initiativesThe treatment of degenerative brain diseases such as Alzheimer sParkinson sand ALS is becoming increasingly important as the current US population ages and life expectancies increaseThe costs of Alzheimer s and other dementias is estimated at over $billion inalonenot ...

PROJECT SUMMARYAcute lung injuryALIand acute respiratory distress syndromeARDSresult from a common pathogenic processpulmonary injury or infection triggers an overwhelming inflammatory responsecytokine stormthat results in increased endothelial and epithelial permeability and efflux of inflammatory cellsproteinand water from the vascular system into the alveolar spaceThe further release of inflamm ...

The broadlong term objective and specific aims of the fast track SBIR research are to create areagentRecombiREDfor use in microinjection of embryos for identifying a subset of embryosas recombination competent injectionsThe ability to quickly identify genome editing events inan embryo allows researcher to quickly make precision animal models of human disease statesPrecise animal models allow for g ...

ABSTRACT Nearlypercent of death and diseaseworldwideis linked to environmental factorsWHOthereforeit is critical that the general public has a basic understanding of how the environment affects their health and how they might protect themselves against environmental exposuresUnfortunatelyenvironmental health is typically covered minimallyif at allin secondary school classroomsMartinaand there are ...

ABSTRACT An Evidence-Based Serious Game Approach for Bullying Prevention Administrative SupplementBullying, in its most familiar form, is a serious public health concern. This is especially true during the middle-school years, a transition period when bullying increases. Cyberbullying, an electronic evolution of face-to-face bullying, is willful and repeated harm inflicted through computers, cell ...