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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A cloud based software platform to enhance reproducibility collaboration and translation of stem cell research

    SBC: Cellara, LLC            Topic: 400

    Project Summary Stem cell research has shown great potential to help treat or even cure a wide array of health conditions including cardiovascular and neurological disease cancer and diabetes This field is now beginning to move rapidly from the re search stage to clinical translation and commercial applications However it has been widely recognized that stem cell scientists have difficulty ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Development and Validation of SafeClose Mesh Augmentation System for Hernia Prevention

    SBC: Paradigm Surgical LLC            Topic: 300

    Incisional hernia IH can be prevented using prophylactic mesh placement PMP which involved placement of mesh to reinforce an abdominal fascia closure before herniation occurs at the index of surgery PMP reduced the absolute risk of IH with an acceptable complication profile Open abdominal surgery techniques remain commonplace and contribute to the estimated cases of IH performed in ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Self crosslinkable hydrogel as an embolic agent for traumatic hemorrhage control

    SBC: Embomedics, Inc.            Topic: 300

    ABSTRACT Trauma is the th leading cause of morbidity and mortality after heart disease malignancies and lower respiratory illnesses in the United States Blunt abdominal trauma BAT is commonly caused by vehicular accidents and falls Uncontrolled bleeding is a major factor in early mortality after trauma contributing to to of trauma related deaths Transcatheter arterial embolization ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Integrated tools for higher order structure determination by cross link analysis

    SBC: Protein Metrics Inc.            Topic: 100

    Summary The use of mass spectrometry MS for quantitative protein characterization has increased dramatically identifying and quantifying thousands of proteins is no longer a heroic task nor is characterizing therapeutic proteins in detail Due to widely available software quantitative mass spectrometry has become routine and widely used for addressing questions in basic biology translational ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a New Carbohydrate based Anticoagulant Drug

    SBC: Glycan Therapeutics LLC            Topic: NHLBI

    Low molecular weight heparins LMWHs a commonly used anticoagulant drug in the hospitals are carbohydrate based molecules Heparin is isolated from porcine intestine through a long and unreliable supply chain LMWH is a depolymerized product of heparin A worldwide distribution of contaminated heparin in impacting the purity and safety of LMWHs was associated with deaths in the US Th ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Development of the first thermolytic to suppress shivering and seizure

    SBC: Be Cool Pharmaceutics LLC            Topic: NHLBI

    Summary The temperature management market is expected to reach $ billion by yet no pharmaceutical has yet been developed specifically for this market A adenosine A AR agonists are well known to attenuate seizure and protect the brain from injury but development of these drugs has been limited by side effects including hypothermia bradycardia and hypotension Inspired by our discover ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Integrated Platform for Mass Spectrometric Studies of Protein Structure

    SBC: Protein Metrics Inc.            Topic: 100

    Summary Technology for studying the higher order structure HOS of biomolecules encompasses some of the most important tools in all of science and is a highlighted NIGMS research topic Mass spectrometric methods for studying HOS include oxidative footprinting and other methods to covalently label amino acid side chain functional groups and also hydrogen deuterium exchange HDX on protein bac ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Novel Probiotic Platform to Treat Necrotizing Enterocolitis

    SBC: Monon Bioventures LLC            Topic: 300

    PROJECT SUMMARY Probiotics hold enormous potential for promoting human health and treating disease One major hurdle to many probiotic products is their lack of persistence in the gut Monon Bioventures MBV and their research partners at the Research Institute at Nationwide Childrenandapos s Hospital RINCH are developing a novel enhanced tunable technology called ProNextTM that allows for a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Small Molecule Therapy for the Treatment of Heart Failure

    SBC: SUMOCOR LLC            Topic: NHLBI

    ABSTRACT The incidence of heart failure HF continues to increase in the United States despite significant advances in pharmacological therapies and novel devices There is an acute need for novel treatment strategies for heart failure A key abnormality in HF is defective handling of calcium that has been partially related to abnormal sarcoplasmic reticulum SR function in cardiac myocytes Red ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. HLS Cyclic CAR peptide a targeted therapy for pulmonary hypertension

    SBC: VASCULAR BIOSCIENCES            Topic: NHLBI

    PUBLIC ABSTRACT This project in response to announcement HLS describes a development program for CARSKNKDC CAR a synthetic cyclic peptide that selectively targets diseased pulmonary vascular endothelium and enhances the therapeutic effect of vasodilator therapies for the treatment of pulmonary hypertension PH PH is a disorder of elevated pulmonary vascular resistance characterized by ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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