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SBC: New England Discovery Partners, LLC Topic: NIAID
AbstractMosquito borne flaviviruses cause disease worldwidewith members such as dengue virusDENVZika virusZIKVand west nile virusWNVinfecting more thanmillion individuals annuallyThe availability of small molecule antivirals that reduce flavivirus infection therefore could have an immediate and substantial impact on public health programs that seek to improve outcomes for populations infected with ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: L2 DIAGNOSTICS LLC Topic: NIAID
ABSTRACT Borrelia miyamotoi is a tick transmitted spirochete recently shown to cause infection and disease in the United StatesEurope and AsiaA member of the relapsing fever group of Borreliathis pathogen has been proven to cause most commonly a nonspecificflu like illness with feverfatiguemyalgiaand headacheDisease can be particularly severe and involve the central nervous system in immunocomprom ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: Parallel Consulting, LLC Topic: 300
Project Summary Today s clinical learning environments do not provide the level of deliberate practicedirect supervisionand rigorous assessment and feedback needed to develop diagnostic reasoning expertiseClinical performance assessment emphasizes learner evaluation over learner developmentlacks rigor and utility for developmental purposesand clinical teachers have expressed particular difficulty ...STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: Tengen Biomedical Co Topic: NIAID
Executive Summary of Predicate SBIR/STTR Phase I Grant and Team TenGen Biomedical Co. and Howard University received an STTR Phase I grant (5R41AI129119-02) from the National Institute of Allergy and Infectious Diseases (NIAID) in 2017. The overall objective of our predicate STTR Phase I grant is to develop a safe, effective, and affordable Zika vaccine based on the novel concept of the third gene ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: TheraBracelet, Inc. Topic: NICHD
Project SummaryPost stroke hand impairment is highly prevalent and severely restricts functional ability and independenceIn facteveryseconds a new stroke occursand stroke is recognized as the leading cause of long term disabilityYetthere is no assistive device to help hand function at homeevery dayduring activities of daily livingExisting devices such as hand opening orthoses are expensivee gMyomo ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Develop technology platform to transform the diagnosing monitoring and treating of opioid use disordersSBC: CARI HEALTH INC Topic: NIDA
PROJECT ABSTRACT There are two big challenges to reducing the number of substance use disorders SUDs in the United States Almost of the million people who suffer from SUDs are never professionally diagnosed and never seek treatment and treatment for the small minority that does seek help is not very effective with relapse rates estimated to be between and within ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: Hura Imaging, Inc. Topic: 100
Project Summary Abstract X ray computed tomography CT has been increasingly used in medical diagnosis currently reaching more than million CT scans every year in the US The increasing use of CT has sparked concern over the effects of radiation dose on patients It is estimated that every CT scans will cause one future cancer i e cases of future cancers from million CT scan ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
A Unified System for Wireless Optogenetics and Brain Microdialysis for Small Molecules Prototype Development and ValidationSBC: AMUZA, INC Topic: 101
PROJECT SUMMARY While optogenetics is well suited for understanding the dynamic activity of neural circuits the first central theme of the NIH BRAIN Initiative PAR its neurochemical impacts remain largely uncharacterized due to a lack of appropriate tools Given that the predominant mode of cellular interactions is neurochemical commercial development of such tools will fulfill the ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: NEXTRAST, INC Topic: 300
Project SummaryAbstract Our long term goal is to revolutionize the effectiveness of CT imaging for millions of Americans across a broad range of abdominal diseaseDual energy CTDECTprovides powerful clinical diagnostic potential but remains heavily underutilized despite wide scanner availabilityDECT allows materials to be differentiated based on their relative X ray attenuation at low versus high e ...STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: PEARL DIAGNOSTICS, INC. Topic: NIAID
Invasive aspergillosisIAcontinues to cause morbidity and death in medically immune compromised patientslargely because we lack sensitive diagnostic tests that are easy to use during high risk periodsWe discovered that fungal galactofuranose containing antigens are excreted in urine of infected animals and peopleusing a novel monoclonal antibodymAbIn a phase I STTRwe engineered a lateral flow devic ...STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health