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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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SBC: Surface Bioadvances, Inc. Topic: NIAMS
Abstract Acne dysbiosis is defined as microbial imbalance with the over growth of Propionibacterium acnes P acnes in the acne microbiome We have demonstrated that Staphylococcus epidermidis S epidermidis a probiotic bacterium co existed with P acnes in an acne lesion can exploit the carbohydrate fermentation to produce short chain fatty acids SCFAs and rein in the over growth of P ac ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: L2 DIAGNOSTICS LLC Topic: NIAID
ABSTRACT Borrelia miyamotoi is a tick transmitted spirochete recently shown to cause infection and disease in the United StatesEurope and AsiaA member of the relapsing fever group of Borreliathis pathogen has been proven to cause most commonly a nonspecificflu like illness with feverfatiguemyalgiaand headacheDisease can be particularly severe and involve the central nervous system in immunocomprom ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: New England Discovery Partners, LLC Topic: NIAID
AbstractMosquito borne flaviviruses cause disease worldwidewith members such as dengue virusDENVZika virusZIKVand west nile virusWNVinfecting more thanmillion individuals annuallyThe availability of small molecule antivirals that reduce flavivirus infection therefore could have an immediate and substantial impact on public health programs that seek to improve outcomes for populations infected with ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: Cavatar LLC Topic: 102
Abstract Caveolae at the endothelial cells surface can selectively rapidly and actively pump targeted antibodies out of the bloodstream and into underlying tissue in vivo even when they are conjugated to high molecular weight cargo Based on this exciting recent discovery we also found that caveolae pumping system enables unprecedented tumor specific targeting and penetration Taken together ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Polyionic Papillomavirus like Particles VLP for the Treatment of HPV oropharyngeal squamous cell carcinomas OPCsSBC: PATHOVAX LLC Topic: 102
The broader impact commercial potential of PathoVax s STTR phase I proposal is to improve outcomes of cancer immuno therapy utilizing a vaccine formulation combining an immunogenic chimeric virus like particle cVLP vaccine with FDA approved immune check point inhibitors PathoVax proposes to develop this technology for treatment of human papillomavirus HPV associated cancers However cancer ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: Tengen Biomedical Co Topic: NIAID
Executive Summary of Predicate SBIR/STTR Phase I Grant and Team TenGen Biomedical Co. and Howard University received an STTR Phase I grant (5R41AI129119-02) from the National Institute of Allergy and Infectious Diseases (NIAID) in 2017. The overall objective of our predicate STTR Phase I grant is to develop a safe, effective, and affordable Zika vaccine based on the novel concept of the third gene ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: PROTEIN METRICS INC Topic: 100
Summary The use of mass spectrometry MS for quantitative protein characterization has increased dramatically identifying and quantifying thousands of proteins is no longer a heroic task nor is characterizing therapeutic proteins in detail Due to widely available software quantitative mass spectrometry has become routine and widely used for addressing questions in basic biology translational ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: TheraBracelet, Inc. Topic: NICHD
Project SummaryPost stroke hand impairment is highly prevalent and severely restricts functional ability and independenceIn facteveryseconds a new stroke occursand stroke is recognized as the leading cause of long term disabilityYetthere is no assistive device to help hand function at homeevery dayduring activities of daily livingExisting devices such as hand opening orthoses are expensivee gMyomo ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: PROTEIN METRICS INC Topic: 100
Summary Technology for studying the higher order structure HOS of biomolecules encompasses some of the most important tools in all of science and is a highlighted NIGMS research topic Mass spectrometric methods for studying HOS include oxidative footprinting and other methods to covalently label amino acid side chain functional groups and also hydrogen deuterium exchange HDX on protein bac ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Assessing Skills and Treatment Progress in Basic Communicators of All Ages The Basic Social and Communication Behavior Scales BSCBS Phase ISBC: PAUL H BROOKES PUBLISHING CO., INC. Topic: NIDCD
Project Summary Abstract Effective communication intervention depends on reliable tools for identifying communication concerns and tracking changes in skills Established tools for detecting and tracking skills in early intentional communicators i e directing a behavior such as reaching toward an adult to convey a message involve communication temptations and assessing a wide variety of child ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health