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SBC: WHOLE BIOME INC. Topic: 400
The human microbiome has emerged as a hitherto unknown causal factor in a number of disease ranging from cancer cardiovascular disease and obesity To understand the biochemical mechanisms of the human microbiome in these diseases researchers must be able to store biochemical pathway transcriptomic and metabolomic datasets in a coherent and compatible form We propose to construct a cloud ba ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: KLEIN BUENDEL, INC. Topic: NIA
DESCRIPTION provided by applicant The United States has the highest rate of incarceration in the world The demographics of the prison population are shifting In fact the number of sentenced state and federal prisoners age or older grew at times the rate of the overall prison population from The health status of aging inmates does not mirror the free world population In fac ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: BIOSYNESIS, INC. Topic: NIAID
DESCRIPTION provided by applicant The yeast Candida albicans is a normal resident of the human digestive tract It is also the most common fungal pathogen of humans causing both mucosal and systemic infections particularly in immune compromised individuals The majority of new C albicans infections arise from the presence of persistent C albicans cells existing in a biofilm These biofilm b ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: TRELLIS BIOSCIENCE, INC. Topic: NIAID
DESCRIPTION provided by applicant About of serious bacterial infections are biofilm mediated Not only do biofilms provide an anchor and physical protection for bacterial cells but the physiology and genetic programming of bacteria also shifts between the planktonic free floating and sessile stationary states Most notably antibiotic sensitivity differs betwen the two states with ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: Gfree Bio, LLC Topic: NIGMS
DESCRIPTION provided by applicant Gfree Bio proposes to collaborate with Professor Bajaj and his group at the University of Texas to develop a general and much more theoretically rigorous algorithm for fitting the ligand binding region of experimental protein ligand cocrystal structures Current methods and practices often lead to very poor geometries for the bound ligand This is a significant ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: CHYNA, LLC Topic: NIDDK
DESCRIPTION provided by applicant We will perform a clinical study to test a novel patented medical food to manage iron deficiency anemia The project is significant because it addresses the number one nutritional disorder in the world and a health problem on the global scale that is second only to tuberculosis in cost worldwide Estimates are that approximately billion people more than ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: ABREOS BIOSCIENCES, INC. Topic: NIAMS
DESCRIPTION provided by applicant Bone loss and fragility from osteoporosis afflict more than million people worldwide including at least million Americans Current osteoporosis treatments are significantly deficient most fail to reverse bone loss and or have adverse effects that prohibit their long term use New therapeutic approaches are urgently needed Recently the TGF family li ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
Superhydrophobic Implantable Surface and D Printing Technology for Targeted Dental Photodynamic TherapySBC: SINGLETO2 THERAPEUTICS LLC Topic: 100
Project Summary Abstract Eradication of bacteria that are located in periodontal pockets is a daunting challenge to dentists and oral care professionals Doxycycline or minocycline with scaling and root planing Sandamp RP have been the mainstays but the field urgently needs further advances in perio bacteria eradication A high precision photochemical implement that could be used simultaneousl ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: REMD BIOTHERAPEUTICS INC. Topic: NIDDK
DESCRIPTION provided by applicant Fast Track Insulin remains the primary and often the only treatment for type diabetes mellitus T D However it is associated with chronic iatrogenic hyperinsulinemia secondary hyperlipidemia higher incidence and severity of cardiovascular complications and life threatening hypoglycemia events A higher mortality vs due to cardiovascular ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: Schell Games LLC Topic: NICHD
DESCRIPTION provided by applicant HIV disproportionately impacts minority adolescents and most of them have neither undergone HIV testing and counseling HTC nor know their status Adolescence is a andquot window of opportunityandquot to intervene with HIV behavior change interventions Challenges to implementing and disseminating some effective HIV prevention programs in adolescents may lim ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health