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Use of Highly Porous Polymer Beads to Remove Anti-A and Anti-B Antibodies from Plasma for TransfusionSBC: CYTOSORBENTS MEDICAL INC Topic: DHP15B001
The ready availability of universal donor plasma to rapidly treat massively bleeding hospital trauma patients and warfighters with combat casualties is a key element of current recommendations for trauma resuscitation, yet universal AB donor plasma is relSTTR Phase I 2016 Department of DefenseDefense Health Agency
SBC: POLARONYX INC Topic: DHP15B002
Based on our success in developing the world first commercial high energy femtosecond fiber laser system and our leading proprietary technology development in ultrashort pulsed fiber laser material processing, PolarOnyx proposes, for the first time, a compact high energy fiber laser based smart wound healing tool to meet with the requirement of this DHP solicitation. It includes a high energy fs f ...STTR Phase I 2016 Department of DefenseDefense Health Agency
SBC: REMD BIOTHERAPEUTICS INC. Topic: NIDDK
DESCRIPTION provided by applicant Fast Track Insulin remains the primary and often the only treatment for type diabetes mellitus T D However it is associated with chronic iatrogenic hyperinsulinemia secondary hyperlipidemia higher incidence and severity of cardiovascular complications and life threatening hypoglycemia events A higher mortality vs due to cardiovascular ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: AllCells, LLC Topic: NHLBI
DESCRIPTION provided by applicant Platelet transfusions are the most effective treatments for patients with thrombocytopenia The growing demand for platelet transfusions is often limited by shortage in the platelets PTL supply due to dependency on volunteer donors short shelf life risk of infections and alloimmunization It is therefore critical to create an efficient donor independent ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: Lipella Pharmaceuticals Inc. Topic: 400
DESCRIPTION provided by applicant This project entails the development of a novel dual component MRI contrast agent formulation for the detecting permeability in the luminal surface of the urinary bladder The purpose of having such a test is ultimately to allow clinicians in certain circumstances to differentially diagnose a chronic non infectious inflammation of the urinary bladder from a ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: COLORADO RESEARCH PARTNERS LLC Topic: NIDDK
DESCRIPTION provided by applicant Intake of added sweeteners high fructose corn syrup and sucrose independently predicts the development of obesity metabolic syndrome and diabetes Despite recommendations by WHO and the AHA to reduce sugar intake to to percent of total energy intake the mean intake of added sugars remains percent of the diet and percent of the population ingest ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: POLARIS HEALTH DIRECTIONS, INC Topic: 100
DESCRIPTION provided by applicant By January oncology care providers will be expected to craft Survivorship Care Plans SCPs for all individuals ending active treatment for cancer however there is a lack of systematic study of the impact survivorship planning has on patients providers or healthcare systems The Polaris Oncology Survivorship Transition POST program is a web based sy ...STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: AADI, LLC Topic: 102
DESCRIPTION provided by applicant In it is estimated that there will be new bladder cancer cases in the United States resulting in deaths Most cases present with nonmuscle invasive bladder cancer NMIBC Intravesical bacillus Calmette Guerin BCG which elicits a nonspecific local immune response is considered the standard first line treatment However ...STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: Molecular Express Inc Topic: NCATS
DESCRIPTION provided by applicant The knockdown of targeted genes by anti sense oligonucleotides ODNS and genetic medicines collectively G MEDS holds promise for a variety of therapies The delivery of effective quantities of ODNS to specific cells however has proved to be challenging We propose here a novel approach to ODN delivery that involves enveloped virus like particles EVLPs ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: KLEIN BUENDEL, INC. Topic: NICHD
DESCRIPTION provided by applicant Vaccinations for adolescents in the U S tetanus diphtheria and acellular pertussis Tdap meningococcal conjugate vaccine MCV Human Papillomavirus HPV vaccines Gardasil and Cervarex remain well below the Centers for Disease Control and Prevention CDC goals and especially so for the HPV vaccines These vaccine deficits are pronounced among minor ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health