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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Enhancing CRISPR based Therapeutic Interventions Via a Targeted Platform Tool

    SBC: ADVANCED TARGETING SYSTEMS            Topic: 100

    Enhancing CRISPR based Therapeutic Interventions Via a Targeted Platform Tool Project Summary The approach described in this proposal anticipates the needs of translational drug development by designing and manufacturing a broadly applicable platform tool that eases CRISPR based therapeutic prioritization modular targeted cell specific delivery of Cas Pursuit of gene therapies for any cell b ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Development of N tert Butyl hydroxylamine NtBuHA as a therapeutic agent for treating Infantile Neuronal Ceroid Lipofuscinosis INCL

    SBC: Circumvent Pharmaceuticals            Topic: 101

    PROJECT SUMMARY ABSTRACT There is a significant unmet medical need for a therapy to treat patients with Infantile Neuronal Ceroid Lipofuscinosis type CLN Batten Disease for which there are andlt in estimated patients in the United States that have no current disease treating options We will begin a pre clinical program on one small molecule that has been selected as a lead compoun ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a Homogeneous Screening Assay for the Tissue Protective EPOR

    SBC: STATEGICS, INC.            Topic: 100

    PROJECT SUMMARY Activators of the tissue protective erythropoietin receptor EPOR c demonstrate encouraging pre clinical and early clinical results for the treatment of Friedreich s Ataxia and Parkinson s disease and hold significant potential for expansion to additional indications In preliminary studies a small molecule scaffold was identified that increased the binding of EPOR extracellular ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Autonomous system supporting patient specific transfer and discharge decisions

    SBC: DASCENA            Topic: 600

    Significance In this SBIR project we propose to improve the utility of AutoTriage a machine learning based clinical decision support CDS system by integrating clinician intervention medical information into its predictions Despite identified needs for CDS systems in patient transfer and discharge decisions existing tools do not meet high standards for sensitivity and specificity This is b ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Development of multispecific antibodies for the treatment of Pseudomonas aeruginosa infection

    SBC: Inhibrx, Inc.            Topic: NIAID

    Abstract Pseudomonas aeruginosa is a major pathogen that causes a wide range of hospital and community acquired infections The greatest obstacle to treating these infections is antibiotic resistance the rising preva lence of multidrug resistant MDR P aeruginosa is a major public health concern Thus there is an urgent need to develop novel therapeutics which can circumvent drug resistanc ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Structure based discovery of dopamine D receptor selective small molecule ligands

    SBC: CONFOMETRX, INC.            Topic: 101

    Dopamine receptors are a family of G protein coupled receptors GPCRs and can be further divided into D like D and D and D like D D and D subfamilies In this proposal we focus on D receptor which is widely expressed in brain at high levels Modulation of D activity is implicated in the treatment of many psychiatric and neurological disorders such as schizophrenia attention def ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. An integrative multi phenotype pipeline for drug evaluation pharmacogenomics and attribute prediction

    SBC: PHENVOGEN LLC            Topic: 300

    PROJECT SUMMARY The process of drug discovery is costly and many promising compounds fail during clinical trials By then expenses upward of $ million dollars per failed drug may have incurred and these financial risks hamper research efforts and ultimately reduce the availability of treatment options In this research proposal we are using systematic approaches to map the relationships be ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Oligonucleotide Inhibition for cardiac regeneration in Ischemia

    SBC: Jaan Biotherapeutics LLC            Topic: NHLBI

    PROJECT SUMMARY Ischemic heart disease IHD is the single largest cause of death worldwide A heart attack or myocardial infarction MI results from limitation of coronary blood flow to the heart causing ischemia and ultimately irreversible death of cardiomyocytes The size of a myocardial infarct correlates with the degree of deterioration of heart function compromise of contractile reserve ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Peripheral FAAH as a target for novel analgesics

    SBC: Anteana Therapeutics Inc            Topic: NIDA

    DESCRIPTION provided by applicant Pain management is a significant unmet medical need Anandamide is an endocannabinoid mediator that plays important roles in the regulation of pain Previous work has shown that endocannabinoid receptors located outside the central nervous system CNS exert a powerful regulatory control over pain initiation The biological actions of anandamide are stopped by ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Development of CaSR nutrient therapy for childhood diarrhea

    SBC: Medosome Biotec, LLC            Topic: NICHD

    Project Abstract Acute infectious diarrhea is a worldwide problem especially among infants young children and immune compromised patients Sadly million children die each year not because of the infections causing diarrhea but due to the associated dehydration The pro absorptive Oral Rehydration Solution ORS is the only recommended oral therapy for children with acute diarrhea yet it ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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