Award Data

DESCRIPTION (provided by applicant): Residents in long-term care facilities and patients in hospitals may exhibit challenging behaviors caused by mental illness. The proposed project will develop an interactive program designed to sharpen the skills of professional staff who work with these residents. Skill-based modules, designed to accommodate users regardless of reading ability, will consist of ...

DESCRIPTION (provided by applicant): It is considered "normal" for an individual grieving the death of a loved one to present with symptoms of depression during the first two months post loss. Nevertheless, these manifestations of bereavement are painful and disrupt social-occupational functioning and quality of life. Moreover, while most will adapt over time, 10-20% are likely to evolve into "co ...

DESCRIPTION (provided by applicant): Demographic shifts within elementary classrooms and school policies regarding main-streaming of all children will require that teachers be trained in working with an increasingly diverse student body. Our review of current diversity training programs for elementary school teachers reveals no interactive multimedia programs to train teachers to effectively work ...

DESCRIPTION (provided by applicant): Our preliminary data support the hypothesis that 552-02 is a potent, selective inhibitor of epithelial sodium channels that is effective in enhancing mucociliary clearance and is well tolerated when administered as a single dose by inhalation aerosol in normal healthy adult volunteers. The general approach to be followed in the continued evaluation of 552-02 du ...

DESCRIPTION (provided by applicant): There are an increasing number of protein drugs in the pipeline, whose cost of production is very high compared to synthetic, small molecule drugs. Further, a number of protein drugs are coming off patent in the next few years, which will create an opening for a market for generic version of these drugs, if they can be produced at significantly lower cost and d ...

DESCRIPTION (provided by applicant): Motivated by the limitations of current synthesis methods for long (30-70 amino acids) peptides, the increasing importance of peptide drugs, and the clear need for low-cost expression and easy purification of peptides, the goal of this Phase I research proposal is to develop the recombinant expression and non-chromatographic purification of functionally active ...

DESCRIPTION (provided by applicant): In the course of previous basic studies in our laboratory, we have developed statistically significant and robust Quantitative Structure-Activity Relationships (QSAR) methodologies, which incorporate rigorous validation procedures and lead to models with a high predictive power and practical utility. The methodologies are built upon the similarity principle, i. ...

DESCRIPTION (provided by applicant): Transplantation of insulin-producing cells in many diabetes patients potentially would restore normal glucose homeostasis and prevent the severe long-term complications of the disease. However, the scarcity of donated pancreata currently limits transplantation of the whole organ or of isolated pancreatic islets to a tiny fraction of those patients who might ben ...

DESCRIPTION (provided by applicant): To make advanced neural stimulator implant devices such as the artifical retina a reality highly flexible minituarized devices with integrated microelectrode arrays for stimulation and integrated microelectronics are needed. Current prototype devices are still too bulky and have many shortcomings in packaging and interconnects to survive long-term in-vivo. One ...

DESCRIPTION (provided by applicant): Prostate cancer (CaP) is the most common malignancy in U.S. males, with over 300,000 new cases per year and almost 50,000 deaths per year. Identification of novel diagnostic markers and therapeutic targets for both incident and advanced CaP is a major goal of current research. First introduced in 1987, the serum level of prostate-specific antigen (PSA) remains ...