Award Data

PROJECT SUMMARYIatrogenic nerve injury is one of the most feared complications of surgery. Nerves are critically important to the function of most tissues and nerve injury can lead to permanent disability. Surgery is performed commonly in the U.S. with approximately 40 million operations annually, incurring up to 600,000 iatrogenic nerve injuries. One procedure particularly plagued by nerve damage ...

PROJECT SUMMARY Millions of Americans currently suffer from Alzheimer’s disease, and the number is expected to escalate rapidly in the coming years. The disease prevalence has a significant financial and emotional impact on families, caregivers, and the healthcare system as a whole. Although there is currently no cure for Alzheimer’s, early disease detection and diagnosis of the disease can pr ...

As sensing, computing, and computational imaging technology advances, it becomes more feasible to integrate them into tightly coupled and fully featured solutions in minimal size, weight, and power – cost (SWaP-C) form factors. In this project, we will develop a camera system for use in a variety of scenarios, from surveillance to targeting systems. Our focus will be building a computational ima ...

PROJECT SUMMARYIatrogenic nerve injury is one of the most feared complications of surgery. Nerves are critically important to the function of most tissues and nerve injury can lead to permanent disability. Surgery is performed commonly in the U.S. with approximately 40 million operations annually, incurring up to 600,000 iatrogenic nerve injuries. One procedure particularly plagued by nerve damage ...

ABSTRACTThis SBIR Phase I proposal requests $178,410.00 (total cost) support for Advantage Silver Dental Arrest, LLC. to develop and assess the technical and scientific feasibility of High Fluoride Toothpaste that also contains Povidone Iodine as a commercial product to arrest dental caries. This proposal responds to the NIDCR Preclinical Research topic: “Preclinical research and development act ...

AbstractPolyfluoro- and perfluoroalkyl substances (PFAS) are a group of highly fluorinated alkanes. Members of this family are known to be persistent and bioaccumulative. PFAS are associated with unfavorable health outcomes in human and animal models. Several public health agencies as well as scientists have published articles that indicate the presence of PFAS in human blood, serum, milk, cord bl ...

PROJECT SUMMARY The overall goal of this application is the translation of a new crosslinkable bone void filler that will allow surgeons to better heal patients after craniofacial bone loss. The bone void filler designed is unique in that it can be implanted as a paste then quickly transition to a solid after initiation with blue light. The ability to transition into a solid after placement is uni ...

Proposal Summary There is increasing appreciation of a syndrome in which patients female patients, present with chest pain due to myocardial ischemia and have a normal or near normal coronary angiogram. Termed coronary microvascular dysfunction (MVD) this disorder is not benign with cardiovascular event rates similar to those with established coronary artery disease. Clinical tools are therefore n ...

The capabilities of native mass spectrometry have improved dramatically in recent years due to advances in instrument speed, resolution, mass accuracy, and ion optics designed specifically to handle large protein complexes. Despite these advances, the depth of characterization achievable by native mass spectrometry is still limited due to inefficient dissociation and fragmentation of large protein ...

Biolytx Pharmaceuticals Corp. is developing a peptide, BP001, derived from the human endogenous host defense protein CAP37, as a novel multi-target ophthalmic product for corneal infections and injuries. The standard-of-care for corneal infections is topical administration of antibiotics that may be accompanied by topical steroids, to limit the destructive effect of the resulting corneal inflammat ...