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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. An adaptive compute solution for characterizing macromolecular complexes by mass spectrometry with electron-based fragmentation

    SBC: E-Msion, Inc.            Topic: 400

    Despite two decades of advances in the speed, resolution and mass accuracy of modern mass spectrometers, the characterization and quantification of biological macromolecules remains a daunting challenge. The remaining weakness with current instrumentation lies in the methods used to fragment macromolecules, which e-MSion is addressing with an efficient electron-fragmentation technology called ExD. ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Online EZY Tai Chi: Simplified 8-Form Program for Individuals with Intellectual Disabilities

    SBC: DOUBLE S INSTRUCTIONAL SYSTEMS            Topic: R

    Project SummaryPeople with intellectual disabilities (ID) commonly have below average motor competence with mobility limitations, especially in the areas of balance and gait, leaving them at high risk for falls and injuries. There is a need for exercise intervention programs that target the specific motor needs of this population. One successful approach to reduce falls in people with ID is Tai Ch ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Single molecule DNA/RNA sequencing technology based on a parallel Raman scattering readout in a coupled nanochannel/nanopore system

    SBC: ARMONICA TECHNOLOGIES, INC.            Topic: 172

    Single molecule DNA/RNA transport and Raman sequencing technology based on parallel Ramanscattering readout in a coupled nanochannel/nanopore system. Abstract Armonica Technologies, Inc. is proposing to develop a novel, high-throughput, label-free, highly accurate, long-read DNA sequencing platform based on inexpensive nanoscale patterning and self- assembly. The platform consists of nanochannels ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Intraoperative Nerve Damage Assessment Using Nerve-Specific Fluorescence Guided Surgery

    SBC: INHERENT TARGETING LLC            Topic: 106

    PROJECT SUMMARY Acute peripheral nerve crush injuries frequently result from closed or open fractures, joint dislocations, and high- energy collisions. Nerve crush, stretch, or transection can lead to functional deficits ranging from numbness to complete motor and sensory function loss, affecting ~1.6M trauma patients annually. Assessment of the degree of injury and the possibility for functional ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. mHealth app for caregiver instruction in manual therapy for chemotherapy-induced peripheral neuropathy

    SBC: COLLINGE AND ASSOCIATES, INC.            Topic: NCI

    Chemotherapy can damage nervous system structures leading to chemotherapy-induced peripheral neuropathy (CIPN) which impairs quality of life and daily functioning for millions of cancer survivors. Some 30% of recipients live with CIPN chronically beyond completion of chemotherapy. Conventional care is symptomatic including antidepressants, anticonvulsants, analgesics, vitamin supplements and topic ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Thrombopoietin Targeting in Myeloproliferative Neoplasms

    SBC: ARONORA INC            Topic: NHLBI

    Project Summary/Abstract Treatment of patients with myeloproliferative neoplasms (MPNs) is limited to palliative and cytoreductive agents that mitigate proliferative blood counts and their effects. Small molecule selective tyrosine kinase (JAK1/JAK2) inhibitors were also shown to provide modest patient benefit, including reduced symptomatology and improved quality of life. Despite the available th ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Development of NH101: A Simple and Efficient Outpatient Dry Powder Amphotericin B-DryNeb(dry powder nebulizer) for Treatment of Susceptible and Multidrug Resistant Aspergillus/ Fungal Infections

    SBC: Nob Hill Therapeutics, Inc.            Topic: NHLBI

    Project Summary The overall objective of this project is to build on the successes of our Phase I SBIR studies to progress NH101: a pure (neat) dry powder of amphotericin B (AMB) combined with the DryNeb™, a novel dry powder nebulizer to “clinic ready” status. The results of this program will enable a Phase I clinical study (AUS), engagement with the FDA on the NH101 505(b)(2) regulatory app ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Fentanyl induces naloxone-resistant vocal cord closure: target validation and development of opioid overdose treatments using a peer-reviewed animal model.

    SBC: TORRALVA MEDICAL THERAPUETICS LLC            Topic: NIDA

    PROJECT SUMMARY: According to the Centers for Disease Control (CDC), synthetic opioids are currently the most common cause of overdose death in the U.S., and have increased opioid deaths by rt500% from 2015- 2020. In 2020 alone, over 80% of the 69,700 opioid deaths were attributed to these synthetics (fentanyl). Despite the widespread availability of naloxone, the only FDA approved treatment for o ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Personal relevance of psychotherapy for Asian Americans: A mHealth problem-solving intervention to reduce stress (PRoP-AA)

    SBC: IRIS MEDIA INC            Topic: 104

    AbstractThe proposed intervention, Personal relevance of psychotherapy for Asian Americans: A mHealth problem- solving intervention to reduce stress, is designed 1) to increase the use of mental health services by a population that uses them at one third the rate of Whites,1 and 2) to develop a personally-relevant approach to stress-reduction. Practical and cultural barriers inhibit the use of men ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Development and testing of a digitally assisted risk reduction platform for youth at high risk for suicide

    SBC: KSANA HEALTH INC            Topic: 104

    ABSTRACTDespite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Although promising approaches are available for preventative interventions with youth at-risk for suicide, they demonstrate modest benefit, and recent reviews have concluded that new developments are required that facilitate not only greater effectiveness, but also enh ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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