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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Rapid Monitoring and Assessment of Tubercuolosis Treatment at the Point of Care Using Breath

    SBC: NanoSynth Materials and Sensors Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Problem and Significance According to the CDC global statistics nearly of the world is infected with Tuberculosis TB In million f peopled infected lived in what is considered a high burden country Countries such as India Peru China sub Saharan Africa and others have significant regions endemic for TB particularly among the lower income ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. TruEnamel: A dental product that treats, protects, desensitizes and whitens teeth

    SBC: TruEnamel, LLC            Topic: NIDCR

    DESCRIPTION provided by applicant Dentin hypersensitivity is a painful condition affecting from of the population It is caused by the movement of fluid in the dentinal tubules and can be eliminated by occluding these patent tubules Tooth whitening is a $ billion business in America and is predicted to grow both here and abroad In this grant we propose a treatment for dentin hypers ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Measuring toxicant effects on cellular function in a microarray format

    SBC: CIENCIA INC            Topic: NIEHS

    DESCRIPTION provided by applicant The EPA maintains a Toxics Release Inventory of over toxic chemicals that are disposed or released from more than industrial sites in the United States The Department of Health and Human Services and USDA maintain a list of over select agents and toxins that pose a severe risk to both human animal and plant health These compounds represent only ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. PDE4B Inhibitors for Treating Brain Injury

    SBC: TETRA DISCOVERY PARTNERS, INC.            Topic: 106

    DESCRIPTION provided by applicant This proposal will develop a new small molecule drug to be advanced into human clinical trials in the chronic post TBI patient who still has chronic cognitive impairments months to years after the initial TBI According to the Centers for Disease Control approximately million Americans suffer from post TBI cognitive impairments This includes people sustai ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Small molecule inhibitors of group II introns for treatment of fungal infections

    SBC: New England Discovery Partners, LLC            Topic: NIAID

    DESCRIPTION provided by applicant This project will result in the development of potent new inhibitors for a novel enzyme target that is specific to the metabolism of fungi and yeast the group II self splicing intron This structurally complex and highly conserved ribozyme plays a key role in RNA processing and metabolic function of lower eukaryotes but it is not present in humans and other v ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Arf6 inhibitors for the treatment of uveal melanoma

    SBC: NAVIGEN, INC.            Topic: 102

    DESCRIPTION provided by applicant Activating mutations in G proteins are the drivers of oncogenesis in numerous cancers Therefore identifying drugs that block the signaling pathways controlled by these mutations could have enormous therapeutic consequences Uveal melanoma is a prototypical G driven cancer in which about of tumors have activating mutations in one of two G encoding genes ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Targeted drug delivery to tumor microenvironment

    SBC: SIBTECH, INC.            Topic: 102

    DESCRIPTION provided by applicant The goal of this project is to test the feasibility of targeted delivery of andquot re programmingandquot liposomal drugs to tumor associated macrophages TAMs TAMs are the major component of tumor microenvironment that generally supports tumor growth and interferes with anti tumor therapy These effects are significantly mediated by about of TAMs that ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Profiling Circulating miRNA Without PCR for Early Detection of Pancreatic Cancer

    SBC: VAJRA INSTRUMENTS, INC.            Topic: 102

    DESCRIPTION provided by applicant Pancreatic cancer PaC has a poor prognosis in most cases due to the lack of early detection owing to its nonspecific asymptomatic nature An effective inexpensive screening tool is needed for early diagnosis within years of tumor initiation It is well accepted that genomic instability is a hallmark of cancer Recent research indicates that less than ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a heterologous bio-production system for the clinically important anti-cancer natural product compound ET-743

    SBC: ALLUVIUM BIOSCIENCES, INC.            Topic: 102

    DESCRIPTION provided by applicant Ecteinascidin ET is a tetrahydroisoquinolone natural product that displays potent anti cancer activity Isolated in very low yields from the marine colonial tunicate Ecteinascidia turbinata ET has been developed by PharmaMar as a cancer chemotherapeutic agent currently marketed in Europe as trabectedin Yondelis r for the treatment of soft tiss ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Targeted Intraceptor Nanoparticle for Macular Degeneration

    SBC: IVEENA DELIVERY SYSTEMS, LLC            Topic: N

    DESCRIPTION provided by applicant Age related macular degeneration AMD is a leading cause of blindness in United States and many other industrialized nations There are two types of AMD the andquot dryandquot and andquot wetandquot forms Dry AMD is a chronic disease that usually causes variable degree of visual impairment In contrast in wet AMD which affects of AMD patients t ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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