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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Hyperphosphorylated tau aggregation kit to identify tauopathy risk factor

    SBC: CAYMAN CHEMICAL COMPANY, INCORPORATED            Topic: NIA

    PROJECT SUMMARY Millions of Americans are suffering from the devastation of cognition decline and other neurological dysfunctions due to one of the neurodegenerative diseases of tauopathy Some of the prominent tauopathies include Alzheimer s disease Pick s disease traumatic brain injury and chronic encephalopathy There is no cure for any of the tauopathies and the actual cause or exogenous r ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Neuro Optical Diagnostic System for Macular Degeneration

    SBC: NEUROFIELDZ INC.            Topic: NIA

    Age related macular degeneration AMD causes progressive loss of central vision and is the leading cause of blindness in the developed world A major challenge in the development of effective treatments for AMD is the lack of sensitive practical visual function endpoints People with AMD manifest delayed dark adaptation DA recovery and DA tests are a FDA approved method for diagnosing AMD Cu ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Therapeutic game based exercise during hemodialysis to improve balance and mobility

    SBC: BioSensics LLC            Topic: NIA

    Abstract Chronic kidney disease CKD disproportionately impacts older adults Balance mobility and falls are serious problems for CKD patients due to associated peripheral neuropathy and peripheral arterial disease which also contribute to foot ulcers and other foot problems in this population Among older adults these problems are often compounded by other comorbid conditions leaving older ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. My MESSAGE Improving Wayfinding and Reducing Challenging Behaviors in Persons with Dementia Through the Use of RFID Technology

    SBC: HEARTHSTONE ALZHEIMER CARE, LTD            Topic: NIA

    In the proposed study we will develop and evaluate a product called My MESSAGE Multimedia Ecopsychosocial Support System for Alzheimer s within Geriatric Environments which will circumvent the limitations of traditional visual cues and also provide unprecedented flexibility and precision for assisting with wayfinding and reducing other challenging behaviors in PWD The target consumer for MM w ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Hit to Lead optimization of small molecule inhibitors of herpes simplex viruses

    SBC: CASTERBRIDGE PHARMACEUTICALS INC            Topic: R

    Herpes simplex viruses and HSV HSV cause a wide range of significant diseases including oral genital lesions corneal blindness and encephalitis HSV and HSV are both transmitted sexually and can infect babies during birth Therapy for HSV relies primarily on nucleoside analogs such as acyclovir ACV which are insufficiently effective and resistant viruses are becoming common amo ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Development of Structure Based Potential for Protein Mapping

    SBC: ACPHARIS            Topic: 100

    The binding sites of proteins include smaller regions called hot spots that are major contributors to the binding free energy and hence are crucial to binding any ligand at that site Hot spots can be determined by screening libraries of fragment sized organic molecules for binding to the target protein by X ray crystallography or nuclear magnetic resonance NMR The computational mapping algori ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Novel methods to improve nuclease mediated homologous recombination

    SBC: ATGC Inc.            Topic: NIGMS

    Abstract Gene correction therapy is one of the most important application directions in regenerative medicine Emerging technologies such as CRISPR clustered regularly interspaced short palindromic repeats Cas CRISPR associated protein Zinc Finger Nuclease ZFN and Transcription Activator Like Effector Nuclease TALEN have enabled efficient and precise gene editing in a wide spectrum of ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Visually driven disease variant analysis empowering real time clinical research

    SBC: Frameshift Labs, Inc.            Topic: NHGRI

    Project Summary Identifying disease causing genetic variants is a complex process that requires experts from multiple fields including bioinformatics IT systems administration and disease pathology to work closely together The size of sequencing data files also adds the requirement for large computational resources As a result performing genomic analyses is an ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Biomimetic Wound Healing Devices to Close Diabetic Wounds

    SBC: Protein Genomics            Topic: NIDDK

    The long term objective of this project is the synthesis and assembly of wound healing devices that mimic as closely as possible the biochemical and mechanical characteristics of healthy human skin The proposed research would focus on the synthesis of membranes containing electrospun human recombinant tropoelastin and collagen mixtures The ratios of the two molecules and the spinning condition ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Quantitative Non Invasive Brain Imaging using Magnetic Nanoparticles

    SBC: TheraNano LLC            Topic: NIDA

    This Phase I STTR project is based upon a new technique Quantitative Ultra short Time to Echo Contrast Enhanced QUTE CE MRI utilizing UTE sequences with SuperParamagnetic Iron Oxide Nanoparticles SPION that leads to quantifiable vascular images with unprecedented clarity and definition QUTE CE is particularly optimal using Ferumoxytol an FDA approved iron oxide nanopharmaceutical The techni ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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