Award Data

In Phase I a revolutionary system for digital imaging microscopy was demonstrated. The system is based on the newly-developed imaging technology of Wavefront Coding (WFC). WFC employs specialized aspheric optics and digital processing to greatly increasethe depth of field or depth of focus. WFC simultaneously decreases the size, weight, and cost of a variety of digital imaging systems. Depth o ...

DESCRIPTION: IL-5 is an essential cytokine for the maturation of eosinophil precursors to eosinophils, and it is those eosinophils that have been found to correlate with the severity of the late asthmatic reaction. Thus, design of IL-5 receptor antagonists that block pulmonary eosinophil disorders and present a new approach to treating allergic asthma. In Phase I, we u ...

DESCRIPTION (Adapted from the application): HER2 is a transmembrane receptor tyrosine kinase overexpressed and amplified in nearly 30 percent of cancers. It is associated with poor prognosis, chemoresistance, and aggressive and metastatic tumor growth. Herceptin, a humanized monoclonal antibody to HER2, is currently available for treatment of metastatic breast cance ...

60768 Present technology vacuum pump power supplies do not provide the features needed for the Next Linear Collider (NLC). Most are located some distance from the pumps themselves, requiring high voltage distribution cables that can break down electrically due to radiation induced damage and cause fires. Those power supplies that do mount on pumps do not have serial control or adequately pr ...

SBIR Phase II proposal is submitted here for evaluation. A compact millimeter-wave waveguide-integrated low loss antenna with a forward tilted fan-beam covering about 90x3.2 degreesis proposed. A total of eight antennas will be integrated into a 4-inchdiameter package. The package also will include at least two sets of oscillator-upconverter modules and four receiver mixers to generate four set ...

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In Phase I CTI demonstrated an innovative, frequency-agile laser source that could tune throughout the midwave infrared spectral region (4-6 um). The source was based on a Cr:ZnSe laser pumping a ZnGeP2 optical parametric oscillator (OPO). Advantages ofthis system include that both the laser and OPO operate well at room-temperature with only passive cooling, the system is amendable to power scal ...

The proposed Phase II program develops a unique meteorological sensor to provide a new capability for volumetric range-resolved wind velocity and aerosol and tracer gas concentration to ranges of several kilometers. The proposed novel sensor is based onexisting CTI-developed commercial off the shelf 2 m pulsed coherent Doppler lidar hardware that is critically augmented with an optical parametr ...

The proliferation of biological weapons among rogue nations and terrorist organizations necessitates that the U.S. develop the means of detecting deployment of these weapons in battlefield, base and civilian settings. Portable and affordable remotesensors that give U.S. forces several minutes warning of approaching threats are necessary so that troops have adequate time to take appropriate protec ...

It is critical to extract maximum information from IR images for target detection, identification and classification systems. The physical information in an image is contained in basically four parameters namely the intensity, phase, polarization andwavelength of the received light. Besides acquiring intensity variations, rapid collection of corresponding polarization signatures at desired wavel ...