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The Award database is continually updated throughout the year. As a result, data for FY22 is not expected to be complete until September, 2023.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Impeller optimization for a combined pump-oxygenator

    SBC: Michigan Critical Care Consultants, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Lung disease is America's third largest cause of death. Adult respiratory distress syndrome (ARDS) afflicts approximately 150,000 patients every year in the US. Lung disease costs the American economy $148 billion yearly in total expenditures. While treatment for heart disease and cancer has been marked by a significant fall in their rates of death (36.6% for h ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  2. Fluorescence lifetime method for guided therapy of brain tumors

    SBC: MICROSURGEON, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): We propose clinical evaluation and optimization studies of time-resolved fluorescence spectroscopy (TR-LIFS) technique for the intraoperative identification of tumor vs. normal brain during neurosurgical resection of brain tumors. A critical need currently for neurosurgeons operating on infiltrative glial neoplasms is the ability to distinguish between normal ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  3. Pre-clinical Feasibility Study of Tissue Oxygenation Imager

    SBC: Modulated Imaging Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Chronic wounds are non-healing wounds such as diabetic ulcers and pressure ulcers. Each year, 6.5 million cases occur in the U.S., costing the economy billions of dollars. Cost-effective and efficient management of chronic wounds depends on quick assessment and diagnosis of the underlying reasons for compromised healing. Ischemia is one of the main complication ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  4. Laboratory mouse identification and inventory control

    SBC: MUSE TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Project Summary: The laboratory mouse is an essential experimental resource for modern biomedical research. Scientists currently use hundreds of varieties and strains of mice, and generate over 10 million individual animals each year. Tens of millions of dollars of NIH funding annually support mouse model research, with millions directly allocated to the mainte ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  5. NANOTEMPLATE ENGINEERING OF A STEALTH MRI CONTRAST AGENT

    SBC: NANOMED PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The increasing costs of therapy and the demonstrated benefits of improved treatment efficacy with early detection are important incentives to develop tumor diagnostic agents of greater specificity and sensitivity. Paramagnetic gadolinium complexes are widely used as MRI (magnetic resonance imaging) contrast agents to improve sensitivity and/or specificity duri ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  6. Formulation & Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention

    SBC: NANOMED PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Despite concerted efforts to improve therapy, five year survival rates for patients with advanced stage oral squamous cell carcinoma (SCC) remain discouragingly low. Clearly, early detection combined with strategies for local intervention, such as chemoprevention prior to SCC development, could dramatically improve clinical outcomes. The results of previously c ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  7. Multiplexed Ultrasensitive Mix-and-Read Tumor Marker Quantification Assays

    SBC: NESHER TECHNOLOGIES INC            Topic: N/A

    DESCRIPTION (provided by applicant): Nesher Technologies, Inc. (NTI) licensed from UCLA the IP for a revolutionary suite of ultrasensitive biodetection technologies involving alternating laser excitation (ALEX) fluorescence spectroscopy. These technologies were developed at the UCLA Single Molecule Biophysics Laboratory (headed by Prof. Shimon Weiss). NTI proposes to apply one of these technologie ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  8. Vaccine Strategies for Candidal Infections

    SBC: NOVADIGM THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Candida is a fungus that is among the most common causes of infections in hospitalized patients in the United States and worldwide. Candida spp. are one of the most common microbes that infect the blood and urine of hospitalized patients. The cost associated with Candida blood infections alone exceeds at least $1 billion per year in the US. Even with therapy, 4 ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  9. Comparative systematic genetics for cardiovascular disease gene identification

    SBC: Fabric Genomics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): This proposal will lead to identification of gene variants that increase the risk of developing cardiovascular disease. The underlying hypothesis is that systematic genetics conducted in model organisms enables the identification of disease-specific gene modules. This hypothesis will be tested in Phase I through the following Aims: (1) Create a database of phen ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  10. High Adherence Ergonomic Oral Positive Airway Pressure Device

    SBC: OPAP, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Development of a miniature orally inserted blower with embedded sensing for the diagnosis and treatment of sleep disordered breathing is proposed. This Oral Positive Airway Pressure (OPAP) device represents a potentially radical change in the interface, machine, and patient adherence of sleep disordered breathing treatment. The ergonomic design of the device w ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
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