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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Vaccine Strategies for Candidal Infections

    SBC: NOVADIGM THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Candida is a fungus that is among the most common causes of infections in hospitalized patients in the United States and worldwide. Candida spp. are one of the most common microbes that infect the blood and urine of hospitalized patients. The cost associated with Candida blood infections alone exceeds at least $1 billion per year in the US. Even with therapy, 4 ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  2. A Wearable Multi-Sensor Navigation Device for the Visually Impaired

    SBC: CASTLEROCK ENGINEERING            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term objective of this application is to develop a wearable multi-sensor way finding device for the visually impaired that can function reliably both indoors and outdoors. The Phase I specific aims are to: 1) assemble and test a hardware platform that consists of a pocket-size computer and four sensors: a wireless signal receiver inside a wearable comp ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  3. Evolutionary Approaches for synthetic Library Design

    SBC: DNA Twopointo Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Directed evolution has been widely employed to enhance protein structural stability and activity, expand functionality and alter specificity. We propose a novel approach for generating libraries of variant genes that takes advantage of the evolutionary history of a gene family by generating a combinatorial library incorporating amino acid replacements inferred ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  4. Carboxylated polysaccharides for drug delivery to the eye

    SBC: BIOPOLYMER INNOVATIONS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Many Americans suffer from ocular diseases which require application of topical therapeutic agents. These diseases range from bacterial conjunctivitis to intraocular inflammation. Keratoconjunctivitis sicca (dry eye) affects nearly 30 million people. Glaucoma affects 2 to 3 million Americans. Topical treatments exist but their ability to deliver drugs to the ey ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  5. A 3-D Interactive Atlas of the Human Skull

    SBC: BROWN AND HERBRANSON IMAGING            Topic: N/A

    DESCRIPTION (provided by applicant): Broad long term objectives and specific aims: The long-term objective of this project is to develop a digital anatomical research resource library of very high-resolution computational models, and imaging data sets. Our objective is to produce an anatomical library otf the complete human skeleton. The implications of this project, both scientific and social are ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  6. NANOTEMPLATE ENGINEERING OF A STEALTH MRI CONTRAST AGENT

    SBC: NANOMED PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The increasing costs of therapy and the demonstrated benefits of improved treatment efficacy with early detection are important incentives to develop tumor diagnostic agents of greater specificity and sensitivity. Paramagnetic gadolinium complexes are widely used as MRI (magnetic resonance imaging) contrast agents to improve sensitivity and/or specificity duri ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  7. Study of CdZnTe Electrode Interface and Fabrication Technology Development

    SBC: Aguila Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): In several recent PA's, the NIH has articulated a clear vision for the future of medical imaging systems a) enhanced spatial or temporal resolution, b) better sensitivity and specificity, c) multi-modality, and d) new functional or molecular imaging or spectroscopy methods. Owing to their unique combination of properties, direct conversion gamma radiation imagi ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  8. High Adherence Ergonomic Oral Positive Airway Pressure Device

    SBC: OPAP, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Development of a miniature orally inserted blower with embedded sensing for the diagnosis and treatment of sleep disordered breathing is proposed. This Oral Positive Airway Pressure (OPAP) device represents a potentially radical change in the interface, machine, and patient adherence of sleep disordered breathing treatment. The ergonomic design of the device w ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  9. An Epithermal Neutron Source for Cancer Therapy

    SBC: ADELPHI TECHNOLOGY INC            Topic: N/A

    DESCRIPTION (provided by applicant): We propose to develop a commercial neutron source for the treatment of brain and liver cancer based on boron neutron capture therapy (BNCT). Boron-containing compounds are injected into a patient's bloodstream and accumulate in a malignant tumor. When irradiated with neutrons, the boron atoms preferentially capture neutrons and decay, releasing short-range radi ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  10. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation

    SBC: CERUS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Delayed reconstitution of antigen-specific immunity following allogeneic hematopoietic stem cell transplantation (HSCT) predisposes patients to opportunistic infections and tumor recurrence. To address these problems, we are developing a vaccination methodology using a non-replicating but highly immunogenic Listeria monocytogenes (Lm) vector. When an Lm vaccine ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
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