Award Data

To address the NGA need for algorithms that fuse observables from over-flight operations and from ground sources to automatically estimatethe degradation of urban environments due to battle damage or natural disasters, Intellisense Systems, Inc. (ISS) proposes to develop a newBayesian Urban Degradation Assessment (BUDA) software system. It is based on the integration of multiple damage assessment ...

Signature Research, Inc. (SGR) and Michigan Technological University (MTU) propose a Phase I STTR effort to develop a learning algorithm which exploits the spatio-spectral characteristics inherent within IR imagery and motion imagery.Our archive of modelled and labeled data sets will allow our team to thoroughly capture the variable elements that will drive machine learning performance.The overall ...

While this solicitation describes the need for better sampling methods and more rugged mass spectrometers to meet this DoD requirement, the topic author agreed to consider our alternative approach, which employs existing DoD Raman spectrometers. The goal of this proposed project (through Phase III) is to develop a Field-Usable Designer Drug Analyzer capable of identifying and quantifying drugs in ...

To address the Chemical and Biological Defense (CBD) need for a field-portable mass spectrometer for small molecule drugs in clinical samples, Physical Optics Corporation (POC) proposes to develop a new FiEldable DRug Mass Analysis (FERMA) system based on a combination of portable mass spectrometry technology with laser desorption/ionization for use with aqueous clinical samples. The FERMA system ...

Chemical warfare agents such as the lethal nerve agent soman are a major source of risk to military personnel. Currently, pyridostigmine bromide (PB) is the only FDA-approved pretreatment to counteract the effects of soman. The rationale behind PB administration is that it acts as a “temporary” inhibitor of AChE. This precludes nerve agents from irreversible inactivation of AChE, thereby mitig ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

Tanner proposes to develop a dynamic heat pump system with self-contained, rechargeable battery and driving circuit that operates as a Combination Thermal Recycler (CTR). By utilizing thermal reservoirs coupled with the rebreather mask, heat can be efficiently recycled in proportion to the temperature difference between the exhaled air stream and a target inhaled air temperature. No power would be ...

The objective of this proposal is to develop a robust, lightweight and compact device for re-heating and maintaining the temperature of a divers inspired breathing gas when diving on a closed circuit underwater breathing apparatus for the duration of the dive. As a solution, Simuleer proposes to develop the Hybrid Energy Abiotic Thermoelectric (HEAT) system based on a high-power hybrid (i.e. passi ...