Award Data

Building interpretable, composable autonomous systems requires consideration of uncertainties in the decisions and detections theygenerate. Human analysts need accurate absolute measures of probability to determine how to interpret and use the sometimes noisy resultsof machine learning systems; and composable autonomous systems need to be able to propagate uncertainties so that later reasoningsyst ...

The National Geospatial-Intelligence Agency (NGA) ingests and analyzes raw imagery from multiple sources to form actionable intelligenceproducts that can be disseminated across the intelligence community (IC). To effectively meet these demands NGA must continue to improveits automated and semi-automated methods for target detection and classification. Of particular concern is furthering NGA's abil ...

Toyon Research Corporation proposes to research and develop algorithms for generalized change detection, by leveraging and exploringexisting and proven effective traditional and deep learning methods, with a unique 3D reconstruction component. The vast majority of themassive amounts of imagery data will have small pixel level differences due to a multitude of unimportant changes: minor misregistra ...

To address the National Geospatial-Intelligence Agency (NGA) need for overhead imagery analysis algorithms that provide uncertaintymeasures for object recognition and aggregation, Intellisense Systems, Inc. (ISS) proposes to develop a new Variational Object Recognition andGrouping Network (VORGNet) system. It is based on the innovation of implementing a Bayesian convolutional neural network (CNN) ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...

Toyon Research Corp. proposes development of a system that automates disaster assessment based on fusion of overhead and ground-basedimages, video, and other data. In Phase I, we will investigate various possible data sources and the benefits of fusing the data in automatedanalysis. We will select and curate data for processing in a Phase I feasibility study. Damage assessment will be performed in ...

To address the NGA need for algorithms that fuse observables from over-flight operations and from ground sources to automatically estimatethe degradation of urban environments due to battle damage or natural disasters, Intellisense Systems, Inc. (ISS) proposes to develop a newBayesian Urban Degradation Assessment (BUDA) software system. It is based on the integration of multiple damage assessment ...

To address the Chemical and Biological Defense (CBD) need for a field-portable mass spectrometer for small molecule drugs in clinical samples, Physical Optics Corporation (POC) proposes to develop a new FiEldable DRug Mass Analysis (FERMA) system based on a combination of portable mass spectrometry technology with laser desorption/ionization for use with aqueous clinical samples. The FERMA system ...