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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. ANTIBODY MICROARRAY FOR DETECTION OF TUMOR MARKERS

    SBC: EIC LABORATORIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this Phase II program is the development of immunosensing microelectrode arrays for use in the screening of multiple tumor markers in blood, urine and tissue samples. The arrays are designed so that

    SBIR Phase II 2004 Department of Health and Human Services
  2. Electrodeposited Noble Metal Oxide Nerve Electrodes

    SBC: EIC LABORATORIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The development of electrodeposited iridium oxide films (EIROFs) as low impedance, high-capacity charge-injection coatings for neural recording and stimulation electrodes is proposed. In Phase I, the biocompatibilit

    SBIR Phase II 2004 Department of Health and Human Services
  3. Rapid Immunoassays for Detecting Pathogenic Bacteria

    SBC: EIC LABORATORIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The development of a hand-held electrochemical immunoassay system for the simultaneous detection of multiple pathogenic bacteria in environmental samples is proposed. The system addresses the need for portable, sen

    SBIR Phase I 2004 Department of Health and Human Services
  4. NEUTRON DETECTORS FOR MACROMOLECULAR CRYSTALLOGRAPHY

    SBC: EIC LABORATORIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Structure-aided drug design requires state-of-the-art crystallography to understand the relationship of protein structure to its function in disease causing organism to lead the way in designing novel effective drugs w

    SBIR Phase I 2004 Department of Health and Human Services
  5. Functionalized Coatings for Enhanced Neural Interfaces

    SBC: EIC LABORATORIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The development of a biologically active polymer coating that promotes the formation of a functionally enhanced and chronically stable nerve-electrode interface for recording and stimulation electrodes used in the cent

    SBIR Phase I 2004 Department of Health and Human Services
  6. Development of a Ras-Targeted Cancer Therapeutic

    SBC: Gene Regulation Laboratories            Topic: N/A

    DESCRIPTION (provided by applicant): The concept of targeting cancer therapeutics towards specific mutations or abnormalities in tumor cells not found in normal tissues has the potential advantages of high selectivity for the tumor and correspondingly low secondary toxicities. At least 20% of all human malignancies display activating mutations in the p21 Ras genes, and perhaps another 60% display ...

    STTR Phase I 2004 Department of Health and Human Services
  7. Pharmacophore-Modeled Screening for HbF-Inducing Agents

    SBC: Gene Regulation Laboratories            Topic: N/A

    DESCRIPTION (provided by applicant): Induction of endogenous fetal globin (HbF) can ameliorate the clinical severity of the beta globin disorders. Many short chain fatty acids and derivatives (SCFADs) stimulate activity from the fetal globin gene promoter, and some create an accessible chromatin structure through HDAC inhibition and histone hyperacetylation. However, the available SCFA drugs requi ...

    STTR Phase I 2004 Department of Health and Human Services
  8. HA Based Opsonokines:A Novel Approach to Tumor Vaccines

    SBC: Genitrix, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): A number of academic groups and companies have focused on the production of cell-based tumor vaccines by cytokine gene transfer. This approach allows sustained local production of the cytokine and maintains a high conc

    SBIR Phase I 2004 Department of Health and Human Services
  9. Integrated Methods to Discover Novel Disease Pathways

    SBC: OSCIENT PHARMACEUTICALS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Our goal is to accelerate the rate of discovery of novel therapeutic agents by rapidly assigning function to genes with no experimental functional data (NEFD) and organizing them within Protein Interaction Network (PIN

    SBIR Phase II 2004 Department of Health and Human Services
  10. Effects of SNPs on Gene Regulation in Complex Diseases

    SBC: OSCIENT PHARMACEUTICALS CORPORATION            Topic: N/A

    N/A

    SBIR Phase II 2004 Department of Health and Human Services

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