List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Long Stroke Wavefront Correctors for Retinal Imaging

    SBC: Boston Micromachines Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): This proposal describes a plan to develop long stroke MEMS deformable mirrors suitable for use in commercial ophthalmic adaptive optics. They will be designed to permit diffraction-limited retinal imaging through dilated pupils in at least 90% of the human population. Electrostatic actuator design and manufacturing processes demonstrated in Phase I research wil ...

    SBIR Phase II 2007 Department of Health and Human Services
  2. Novel Therapeutic Agents for ALS

    SBC: CAMBRIA BIOSCIENCES, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. The worldwide prevalence of ALS is estimated at ~87,000 patients, in part due to the low median survival of 3 to 5 years post diagnosis. Riluzole is the sole drug currently approved for the treatment of ALS and only extends the surviv ...

    SBIR Phase I 2007 Department of Health and Human Services
  3. COMPOUNDS ACTIVATING DJ-1 AS THERAPEUTICS FOR PARKINSON'S DISEASE

    SBC: CAMBRIA BIOSCIENCES, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Parkinson's Disease, the second most common neurodegenerative disorder, is a complex multifactorial disease with no known disease-modifying therapeutic treatments. DJ-1 is one of the most frequently mutated genes in patients with early-onset familial parkinsonism, and a number of findings from our studies and others indicate that this broadly distributed and hi ...

    SBIR Phase I 2007 Department of Health and Human Services
  4. Spectrally resolved tomographic small-animal fluorescence imager

    SBC: CAMBRIDGE RESEARCH AND INSTRUMENTATION            Topic: N/A

    DESCRIPTION (provided by applicant): This is a Fast-Track proposal to develop a multispectral optical tomography small-animal imaging system for use by the biomedical and pharmaceutical research communities. It will combine the experience CRI has acquired in multispectral, planar small-animal imaging (through its development of the Maestro(tm) system) with novel hyperspectral optical tomography a ...

    SBIR Phase I 2007 Department of Health and Human Services
  5. Cellularly resolved molecular pathway assessment in biopsies via spectral imaging

    SBC: CAMBRIDGE RESEARCH AND INSTRUMENTATION            Topic: N/A

    DESCRIPTION (provided by applicant): This is a Fast-Track application to provide reliable, cellularly resolved molecular pathway assessment in cancer biopsies to assist pharmaceutical drug development and provision of patient-specific prognosis and therapy guidance ( personalized medicine ). The organizing theme is that the appropriate unit of analysis should be the individual cell as oppo ...

    SBIR Phase I 2007 Department of Health and Human Services
  6. Salivary Osmometry: A Novel Paradigm in Point-of-Care Hydration Assessment

    SBC: CANTIMER, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Dehydration poses a significant and costly problem in medical care. As an example, literature estimates that 30-50% of all skilled nursing facility residents are chronically dehydrated, with resulting cost to the medical system exceeding $1 billion dollars annually. In the pediatric realm, it is estimated that over 2,000,000 deaths occur worldwide every year du ...

    SBIR Phase I 2007 Department of Health and Human Services
  7. A New Preparation and Analysis System for the CBC

    SBC: CELL IMAGING SYSTEMS, LLC.            Topic: N/A

    DESCRIPTION (provided by applicant): The Complete Blood Count (CBC) is the most commonly performed clinical laboratory test in the United States and the world. A new technology for the CBC is proposed, which produces a monolayer of whole blood and uses computer image analysis. The system will be compact and much less expensive than current CBC instrumentation, which is based on multi-channel, mult ...

    SBIR Phase II 2007 Department of Health and Human Services
  8. Finding Acetylated-Lysine Sites in the Cancer Proteome

    SBC: CELL SIGNALING TECHNOLOGY, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Recent studies indicate acetylated-lysine is an under-appreciated post-translational modification with a potentially prominent role in cancer biology. However, despite advances in proteomics, it is still difficult to find lysine acetylation sites in proteins. Although IMAC can be used to isolate phosphorylated peptides in bulk, there is no bulk purification te ...

    SBIR Phase I 2007 Department of Health and Human Services
  9. SBIR TOPIC 229 DETECTION OF ONCOGENIC TARGETS BY MULTIPLEX BEAD ELISA

    SBC: CELL SIGNALING TECHNOLOGY, INC.            Topic: N/A

    N/A

    SBIR Phase I 2007 Department of Health and Human Services
  10. PhosphoSite. and the Phosphoproteome of Cancer

    SBC: CELL SIGNALING TECHNOLOGY, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): PhosphoSite(r) and the Phosphoproteome of Cancer Protein kinases and their substrates are important regulators of signal transduction pathways during normal growth and development as well as during oncogenesis. PhosphoSite is a bioinformatics resource that systematically has collected information from thousands of published reports about specific phosphorylatio ...

    SBIR Phase II 2007 Department of Health and Human Services

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government