List

Despite major advances in genome sequencing and identification of the genetic basis of diseaseclinical use of genomic analysis is limited in part by the costs and coordination associated with correlating genome results with phenotypic findingsSegalClinicians are overwhelmed by the huge amounts of information needed to assess a genomeand laboratory scientists are hampered by getting sparse informat ...

AbstractDiabetic neuropathic painDNPis one of the most common and difficult to treat complications of diabetesCurrent therapiesdo not directly address the fact that pain sensation is processed in the brainand most act at the neuropathy sitei ein the peripheryalthough DNP patients also have a central pain component due to their injuryDNP symptomatology correlates with chronic pain induced changes i ...

PROJECT SUMMARY Alzheimerandapos s Disease is a neurodegenerative disease characterized by a progressive decline in cognitive function and a corresponding accumulation ofamyloid plaques and neurofibrillary tanglesthe two hallmark pathologiesDrugs currently available to AD patients manage the disease symptoms by improving neuronal activitybut efficacy diminishes as the disease advancesIn tauopathie ...

Human immunodeficiency virusHIVassociated neurocognitive disorderHANDrepresents a major chronic health problem in the US and abroadMagnetic Resonance ImagingMRIstudies have consistently shown brain gray and white matter abnormalities and cognitive deficits in patients with HANDAdvances in treatment of HAND have been made by delivering drugs or viral vectors that can increase brain derived neurotro ...

ABSTRACT Alzheimerandapos s diseaseADis one of the largest global public health crises facing us todayyet there are no effective therapies available to preventdelayor slow AD progressionDominant approaches based on a set of prevailing core hypotheses about druggable pathways and targets have failedThereforethere is a need for novel and alternative pathways distinct from those pursued over the past ...

Project SummaryThe CDC lists MDR Neisseria gonorrhoeaeNgas one of the three most urgent antibiotic resistance threats in the United StatesA Gram negative fastidious organismNg causes gonorrheathe second most prevalent sexually transmitted bacterial infectionSTIwith andgtestimated cases in the United States annuallyLeft untreatedgonorrhea can cause pelvic inflammatory disease in womenleading to fal ...

Abstract Worry is a habitual thought process that is observed in individuals with anxiety disordersA leading theory posits that although worrying may be unpleasantthe immediate emotions that are avoided by concentrating on worry are often perceived as more aversiveegfearangergriefFrom a mechanistic perspectiveworry is thought to be learned and reinforced in a similar manner to other types of opera ...

Project SummaryAbstract The neurofibromatosesNFsincluding NFNFand schwannomatosisare a group of autosomal dominant neurogenetic disorders characterized by a predisposition in virtuallyof patients to develop multiple nerve sheath tumorsThe determination of tumor burden on magnetic resonance imagingMRIis indispensable for the longitudinal management of NF patientswhich includes life long follow up f ...

PROJECT SUMMARY! Peptide therapeutics combine high potency and selectivityand engender fewer side effects than traditional small moleculesThis has fueled interest in peptides filling the gap between `biologicsandaposand small molecules as compounds that have key desired properties from both the other classesThere are however some challengesthe major one being susceptibility to enzyme catalyzed hyd ...

ABSTRACT The goal of this project is to develop a based computer aided diagnosisCADalgorithm for identification of regions at risk for developing esophageal adenocarcinomaEACin optical coherence tomographyOCTscans of the esophagusEAC is one of the deadliest cancers with ayear survival rate of less thanyet the standard of care for detecting precursors to EAC is widely recognized to be inadequateJus ...