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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel anti infectives for Clostridium difficile infection

    SBC: Exarca Pharmaceuticals, LLC            Topic: NIAID

    SUMMARY Clostridium difficile infection CDI is now the countryandapos s leading cause of antibiotic associated diarrhea and has increased acute care facility costs by $ billion per year CDI was originally restricted to health care settings but is now responsible for community acquired infections as well The infection toll is now approaching cases per year leading to andgt f ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. New Approaches to Mining the Complete Actinomycete Genome to Discover Novel Beta Lactam Antibiotics

    SBC: WARP DRIVE BIO, LLC            Topic: NIAID

    ABSTRACT There is a critical need to discover and develop safe and effective antibiotics for the treatment of multidrug resistant bacterial infections Each year approximately million patients in the US get hospital acquired infections HAIs with a mortality rate of Nearly of the bacteria causing HAIs are resistant to at least one commonly used antibiotic Natural products NPs an ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Rapid Detection of multiple sepsis pathogens

    SBC: TANGEN BIOSCIENCES, INC.            Topic: NIAID

    Abstract Sepsis is a major public health concern and the primary cause of death in the intensive care unit accounting for more than $ billion of total US hospital costs in Sepsis can lead to a life threatening drop in blood pressure termed septic shock which can quickly lead to the failure of vital organs such as lungs kidneys and liver and eventually to death Nearly all sepsi ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. On Body Passive RFID Antenna Array and Testbed to Assess Changes in Bone Structure

    SBC: NEVA ELECTROMAGNETICS LLC            Topic: NIAMS

    PROJECT SUMMARY ABSTRACT More than million Americans have osteoporosis and an additional million have low bone density or osteopenia Osteoporosis represents a major health problem resulting in substantial increases in national health care costs Current methods to detect osteoporosis rely upon ionizing techniques such as Dual energy X ray Absorptiometry DXA and Quantitative Computed To ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Serologic assays for detection of Zika virus antibodies for clinical diagnosis and blood donor counseling

    SBC: Kephera Diagnostics, LLC            Topic: NIAID

    Project Summary Zika virusuntil recently an obscure mosquito borne flavivirus from Africahas emerged rapidly within the past two years as a major threat to public health in the Western HemisphereHaving traveled across the Pacificit has become endemic in Brazil and is expanding its territory northwards in South and Central AmericaMexico and the Caribbeancarried by a similarly expanding Aedes mosqui ...

    SBIR Phase I 2017 Department of Health and Human Services
  6. Novel Antibiotics from Marine Invertebrate Microbes

    SBC: NOVOBIOTIC PHARMACEUTICALS, LLC            Topic: NIAID

    ABSTRACTThe rise of multi drug resistant pathogensparticularly ESKAPE pathogensis a major public health concernOne effective countermeasure against such pathogens is novel antibioticsbut the rate of antibiotic discovery has been in steady declineOne particularly promising source of novel antibiotics is microbial species because most of them have never been cultivated or exploredThis is especially ...

    SBIR Phase I 2017 Department of Health and Human Services
  7. Handheld Two Photon Microscopy Imager

    SBC: Physical Sciences Inc.            Topic: 102

    Project Summary Abstract Physical Sciences Inc PSI proposes to develop a handheld two photon microscopy TPM probe that will enable in vivo diagnosis and screening of various diseases including cancers This novel clinically usable TPM instrument will provide three dimensional D sub micron resolution images of tissue pathology in situ The images generated based on the two photon excitat ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Automated System for High Yield Pancreatic Islet Isolation

    SBC: CG Scientific, Inc.            Topic: 200

    Project Summary Abstract This project aims to develop an automated system for reproducible high yield pancreatic islet isolation to greatly improve islet transplantation and benefit patients who suffer type I diabetes T D The new system will use state of the art technologies CG Scientific s patent pending automated cell isolation platform ACIP and its proprietary no islet left behind NI ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. INHIBITORS OF CELLULAR TRANSPORTERS FOR THE TREATMENT OF TNBC

    SBC: Nirogyone Therapeutics LLC            Topic: NCI

    INHIBITORS OF CELLULAR TRANSPORTERS FOR THE TREATMENT OF TNBC Abstract Triple Negative Breast CancerTNBCis defined by the receptor status of the cellsTNBC does not express estrogenprogesteroneor HerreceptorsIt is estimated thatmillion women worldwide are diagnosed with breast cancer each yearTNBC is the most deadly sub type of breast canceraccounting forof the breast cancer diagnoses andof breast ...

    SBIR Phase I 2017 Department of Health and Human Services
  10. Magneto electronic Sensing of Cancer in Urine

    SBC: Accure Health Inc.            Topic: 102

    MAGNETO ELECTRONIC SENSING OF CANCER IN URINE PROJECT SUMMARY ABSTRACT Bladder cancer is the fth most common cancer in the United States and one key challenge for bladder cancer is the high recurrence rate after initial treatment Furthermore a number of medical and environmental conditions are associated with higher incidence of bladder cancer Therefore regular surveillance of bladder canc ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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