Award Data

Abstract SignificanceAtrial fibrosis plays a central role in the development of atrial fibrillationAFand heart failurewhich are both common conditions in the elderly and associated with significant morbidity and mortalityThis proposal addresses an unmet diagnostic need for non invasive methods to characterize atrial fibrosis through non invasive molecular imaging of typecollagenthe hallmark pathol ...

NIH through NIDA solicits the research and development of digital markers for detection of marijuana intoxication and cognitive impairmentIn this Project the ContractorCharles River Analyticsin partnership with the SubcontractorMcLean Hospitalproposes to design and demonstrate a prototype system for the Specification of Acute THC Impairment using Validated AlgorithmsSATIVASATIVAingests data across ...

ABSTRACT A large number of studies require sampling biological signals stimulating the brain or infusing test substances in freely moving mice Although several forms of tethers are currently available for this purpose these devices restrain the mice s activity to some degree The animal s mobility is usually reduced even more when several connections are needed with the mouse i e electroenc ...

Project SummaryFiloviruses cause severe hemorrhagic fevers and are among the deadliest human viruses with no approved treatment or prophylactic optionsPeriodic outbreakssuch as the recent epidemic of Ebola virusEBOVin West Africaexhibit mortality rates ranging fromThey are classified asCategory A priority bioweapon agentsby the Centers for Disease Control and PreventionThe most advanced candidates ...

PROJECT SUMMARY Glaucoma affects overmillion peopleIt is the leading cause of irreversible blindness worldwideEye drop medications are available for treatment of glaucomahowevernearly half of all glaucoma patients do not fully comply with their prescribed eye drop regimensand many continue to lose vision in spite of available therapyThere is a significant need for sustained release drug delivery s ...

The goal of this Phase I SBIR proposal is to test the feasibility of an intra tissue antimicrobial surgical wound matrix in the prevention of superficial surgical site skin infections Surgical Site Infections SSI are the second most common type of health care associated infection HAI occurring in to of patients undergoing surgery in the United States and accounting for approximately ...

Preceding Award: NCI Award 1R44CA192875-02 Project Summary: According to the Oral Cancer Foundation, about 50,000 people in the US will be newly diagnosed with oral cancer (OC) in 2017, causing 9,700 deaths[1]. OC is a severely neglected orphan disease with a lack of significant treatment advances in 4 decades[1]. Historically, OC has been present in heavy smokers and drinkers. However, more recen ...

Project Summary/AbstractMore than 34 million Americans provide unpaid care for an adult 50 years of age or older. Of these informal caregivers, approximately 60 to 70 percent report being employed while providing care. Caring for a relative while working outside of the home can take a heavy toll on caregivers’ health. Working caregivers have poorer health than non-caregivers, as measured by perc ...

Abstract The project concerns optical single molecule sequencing on a highly packed array of molecules in which individual molecules are not resolvable by standard diffraction limited imagingThe sequence of molecules is obtained by super resolving signal from individual molecules during the course of template directed DNA synthesisThe project willsynthesize and test the basic building blocks of th ...

ABSTRACT The goal of this PhaseSTTR project is to demonstrate the efficacy of a novel class of proteoglycanmimic biopolymers for the treatment of interstitial cystitis bladder pain syndromeIC BPSIC BPS is a chronic disease characterized by lower pelvic painurinary urgency and frequencyand urge incontinenceChronic pain results from a disruption of the protective glycosaminoglycanGAGlayer of the lum ...