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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Virus-Targeted Therapy for Malignancies

    SBC: Phoenicia Biosciences, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Epstein-Barr virus (EBV) is associated with a number of human malignancies for which there are presently few effective treatments. Lymphoid malignancies caused by, or associated with, Epstein-Barr virus include Burkitt's lymphoma, T/NK lymphomas, some T- and B-cell lymphomas, approximately half of Hodgkin's lymphomas and all post-transplant lymphopro ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  2. Rapid Testing of Drug-Resistant BCR-ABL(+)Leukemia Cells

    SBC: BIOSENSE TECHNOLOGIES, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Resistance to chemotherapeutic drugs is an ongoing problem that results in eventual treatment failures or suboptimal patient outcomes. In cancer cells treated with drugs to which they are sensitive, the stress responseis the first step in the subsequent cascade leading to cell death (apoptotic, necrotic or autophagy). The recent availability of a sensing modali ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  3. Contrast agents for high-sensitivity ultrasound molecular imaging of tumor angiog

    SBC: TARGESON, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Molecular imaging techniques have strong potential in the setting of preclinical research, primarily for drug discovery and basic science in the field of cancer research. In particular, high-frequency ultrasound is a powerful imaging modality for phenotyping and monitoring the response to experimental therapy. Relative to other molecular imaging techniques, ult ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  4. Global Proteomic Screening by MALDI Spectrometric Imaging of Protein-Bead Arrays

    SBC: AMBERGEN, INC            Topic: NCI

    DESCRIPTION (provided by applicant): Sequencing of the human genome has led to a new and even more ambitious goal - characterization of the human proteome. Such an endeavor involves not only understanding the function of hundreds of thousands of differentproteins expressed in human cells but also characterizing the millions of potential interactions that can occur with other cellular and extracel ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  5. Developing a plectin-1 targeted imaging agent for the detection of pancreatic can

    SBC: iTi Health            Topic: NCI

    DESCRIPTION (provided by applicant): Pancreatic ductal adenocarcinoma (PDAC) is an intractable clinical problem, typically presenting with metastasis at the time of diagnosis and exhibiting profound resistance to existing therapies. Currently, the standarddiagnostic course includes CT or MRI scans which do not have optimal sensitivity and specificity for accurately diagnosing and determining resec ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  6. A Clinical Decision Support Tool for Electronic Health Records

    SBC: Inflexxion, Inc.            Topic: NIDA

    DESCRIPTION (provided by applicant): Substance abuse treatment is often complicated by problems such as depression, family and interpersonal conflicts, and legal issues. When these issues are addressed with effective, evidence-based treatments (EBTs), outcomes improve. To improve the quality of addiction treatment, experts have called for the adoption of a continuing care management approach, invo ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  7. ACES: A Product to Suppress or Enhance Critical Components in Acoustic Signals

    SBC: Speech Technology and Applied Research Corporation            Topic: NIDCD

    DESCRIPTION (provided by applicant): Common acoustic environments are often complex mixtures of sounds from multiple acoustic sources. Some of these sources contain critical information listeners need to comprehend; others are distractions that interfere with listeners6 comprehension. As the US population ages, a significant and growing segment have difficulty coping with such complex sound fi ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  8. Optical Surgical Probe for Assessing Human Oral Mucosa Graft Vascularization

    SBC: RADIATION MONITORING DEVICES, INC.            Topic: NIDCR

    DESCRIPTION (provided by applicant): This proposal's main objective is the development of a novel Perfusion Monitoring Device (PMD) based upon diffuse correlation spectroscopy (DCS), which will enable microsurgeons to assess the level of vascularization ofburied (prelaminated) flaps and the successful perfusion of transplanted microvascular grafts. The PMD will shift current assessment of bur ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  9. MMP Inhibitor For Orofacial Pain

    SBC: AQUILUS PHARMACEUTICALS INC            Topic: NIDCR

    DESCRIPTION (provided by applicant): Aquilus Pharmaceuticals, Inc. proposes to evaluate the effects of a novel matrix metalloproteinase (MMP) inhibitor on animal behavioral models of spinal and orofacial neuropathic pain. The goals for Phase I are to scale-up the synthesis of the inhibitor, determine its pharmacokinetics (PK) and then run animal efficacy studies in both the spinal nerve ligation ( ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  10. Nano-Crystalline Ceramic Coatings for the Reduction of Sliding Resistance of Orth

    SBC: Spire Corporation            Topic: NIDCR

    DESCRIPTION (provided by applicant): In this program, nano-crystalline ceramics will be applied to the surface of orthodontic archwires using ion beam assisted deposition (IBAD) to reduce sliding resistance. Excessive sliding resistance works against toothmotion as the bracket slides along the wire into a new position, resulting in less predictable outcomes, and requiring increased force, treatmen ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
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