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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Continuous Oxygen Monitor for Patients on Long-Term Oxygen Therapy (COMPLY)

    SBC: BARRON ASSOCIATES, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is responsible for more than 500,000 hospitalizations and over 100,000 deaths in the United States annually. COPD is currently the fourth leading cause of death; it is projected to become the third leading cause of death in the U.S. by 2020 and worldwide by 2030. Long-term oxygen therapy (LTOT), which is administered ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. Bifunctional Redox Agent for the Treatment of PPHN

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening neonatal condition wherein an elevation in pulmonary vascular resistance after birth diverts pulmonary blood flow via a right-to-left shunt,at the levels of the ductus arteriosus and foramen ovale, into the systemic circulation. Current therapy includes mechanical ventilation, oxygen, ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. 12-lead MRI-Compatible ECG for physiological monitoring and scanner synchronizati

    SBC: E-TROLZ, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): This SBIR project aims to develop an MRI-compatible 12-lead ECG system. Such a system will provide greatly improved physiological monitoring inside the MRI, which is important for imaging severely ill patients (stroke, spine, patients with ischemic histories), and is also key to future MRI-guided interventions and surgeries. Current MRI-compatible ECG monit ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Intramural drug infusion balloon for preventing vascular restenosis

    SBC: MEDI-SOLVE COATINGS, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Recently, drug coated balloons (DCB) have emerged as a promising alternative for treating stenosed arterial vessels. The demonstrated efficacy of DCB is tempered by the risk of distal arterial embolism, which can resultfrom systemic drug exposure caused by premature dissolution or delamination of the drug coating into the blood stream during catheter insertion ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Laser Catheter for Bronchial Treatment of Severe Asthma

    SBC: Biotex, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Asthma afflicts as many as 39 million Americans and some 4,000 will die of the disease each this year. The goal of this Phase I SBIR proposal is to design, develop, build, and test a novel, cooled laser catheter for effecting Bronchial Thermoplasty in a safe and efficient manner. Bronchial Thermoplasty is a relatively new term which refers to destruction of the ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Development of HeartLander as an epicardial injection delivery system

    SBC: HEARTLANDER SURGICAL, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Numerous innovative therapies that must be delivered into the heart wall are now under development. These therapies typically require precise placement of a precise measure of an injectable substance and are intendedto be delivered by minimally invasive means to minimize patient trauma. Unfortunately, traditional approaches for delivering such therapies, suc ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. NEURON2GPU: Transformative Neural Simulation Using Desktop GPU Technology

    SBC: INFORMED SIMPLIFICATIONS, LLC            Topic: NIMH

    DESCRIPTION (provided by applicant): Researchers are now able to perform computational physiology and pharmacology experiments on realistic model neurons with accurate geometries and full complements of membrane biophysics and biochemistry; however, the practical utility of such simulations are restricted because of the limitations of current commodity computer hardware. We will provide real time, ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Motivational Interviewing: An Experiential Online Training Tool

    SBC: C4 Innovations, LLC            Topic: NIMH

    DESCRIPTION (provided by applicant): The Center for Social Innovation (C4SI) proposes to develop and pilot test the Motivational Interviewing Simulator: An Experiential Online Training Tool. Motivational Interviewing (MI) is a well-established evidence- based practice that has been implemented across a wide range of disciplines including mental health and substance abuse treatment, primary care, H ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. Web-Based Program to Improve Antidepressant Medication Adherence

    SBC: ISA ASSOCIATES INC            Topic: NIMH

    DESCRIPTION (provided by applicant): Mood disorders, including major depressive disorder, dysthymia, and bipolar disorder, affect nearly 21 million Americans or 9.5% of the U.S. population age 18 years of age and older. Among mental health problems, majordepressive disorder is the leading cause of disability in the U.S. for people ages 15-44, affecting nearly 15 million adults each year. While res ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Inkjet Based System for Lipid Cubic Phase Crystal Screening of GPCR's

    SBC: MicroFab Technologies Inc            Topic: NIMH

    DESCRIPTION (provided by applicant): In this project, we propose to develop new instrumentation to perform crystallization screening of brain-derived G-protein coupled receptors (GPCRs) and other membrane proteins to obtain highly ordered crystals for X-ray diffraction and molecular structure determination. This instrument (LCPJet) will employ lipidic cubic phase (LCP) protein crystallization tech ...

    SBIR Phase I 2011 Department of Health and Human Services

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