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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. DRUG THERAPY FOR HYPERCALCEMIA/BONE RESORPTION

    SBC: MACROCHEM CORPORATION            Topic: N/A

    CURRENT DRUG THERAPY FOR HYPERCALCEMIC DISEASES INVOLVING BONE RESORPTION IS OF LIMITED EFFECTIVENESS. PRELIMINARY ANIMAL TESTING HAS SHOWN BENZO(B)THIOPHENE-2-CARBOXYLIC ACID(THIONAPTHENECARBOXYLIC ACID, TNCA) TO BE OF POTENTIAL USE IN INHIBITING BONE RESORPTION. OVERALL PROJECT GOALS ARE TO DEVELOP TNCA AND ITS DERIVATIVES AS NOVEL THERAPEUTIC ENTITIES IN THE TREATMENT OF HYPERCALCEMIA OF MALIGN ...

    SBIR Phase I 1988 Department of Health and Human Services
  2. MICROWAVE STERILIZER FOR CAPD STERILIZER

    SBC: MERIDIAN MEDICAL SYSTEMS, LLC            Topic: N/A

    ACUTE OR CHRONIC FAILURE OF THE KIDNEYS RESULTS IN RAPID DEATH UNLESS NORMAL KIDNEY FUNCTION IS REPLACED BY DIALYSIS.DIALYSIS PURIFIES THE BLOOD IN A SELECTIVE WAY, REMOVING TOXIC SUBSTANCES VIA A SEMI-PERMEABLE MEMBRANE, OR FILTER. HEMODIALYSIS EMPLOYS AN ARTIFICIAL EXTRACORPOREAL MEMBRANE WHICH NOT ONLY RESTRICTS THE FREEDOM OF THE PATIENT, BUT IS ALSO ASSOCIATED WITH VARIOUS SIDE EFFECTS. PERIT ...

    SBIR Phase I 1988 Department of Health and Human Services
  3. OPTIMIZING MICROWAVE SCANNING TO DETECT BREAST CANCER

    SBC: MERIDIAN MEDICAL SYSTEMS, LLC            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  4. CERAMIC MATERIALS FOR IMPROVED CONTACT LENSES

    SBC: Merix Corp            Topic: N/A

    IN THIS PROGRAM, THIN SHEETS OF OPTICALLY CLEAR, CERAMIC MATERIALS WILL BE PRODUCED AND FABRICATED INTO LENSES FOR EVALUATION AS CONTACT LENS MATERIALS. THE MATERIALS WILL PERMIT HIGH OXYGEN FLUX TO AND FROM THE CORNEA, PREVENTING ATOXIA AND SHOULD HAVE HIGH WETTABILITY. THEY WILL ALSO BE STRONG, HARD AND RESISTANT TO HARD LENS CLEANING SOLUTIONS. INITIAL EVALUATION WILL INCLUDE OPTICAL PROPERTIES ...

    SBIR Phase I 1988 Department of Health and Human Services
  5. IMPROVED BILE ACID ADSORBENTS

    SBC: Merix Corp            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  6. RAPID AND AUTOMATED IN VITRO TEST SYSTEM FOR SCREENING ANTICANCER AGENTS

    SBC: Microdrop/intellimetrics            Topic: N/A

    WE PROPOSE RESEARCH AND DEVELOPMENT DIRECTED TOWARDS AN IMPROVED AND MOSTLY AUTOMATED IN VITRO MAMMALIAN LONG TERM SURVIVAL ASSAY (CLONOGENICITY) TO BE USED FOR SCREENING ANTICANCER DRUGS. THE METHODS UNDERLYING THIS APPROACH ALLOW RAPID MEASUREMENTS ON LARGE NUMBERS OF CELLS AND COLONIES WHICH CAN BE MOSTLY AUTOMATED, AND WHICH CAN BE USED UNDER A WIDE VARIETY OF CELL CULTURE AND CYTOTOXICITY ASS ...

    SBIR Phase I 1988 Department of Health and Human Services
  7. KINEMATIC ANALYSIS OF PEDIATRIC MOVEMENT DISORDERS

    SBC: Moco, Inc.            Topic: N/A

    THE OBJECTIVE OF THIS RESEARCH IS TO INVESTIGATE WHETHER KINEMATIC PROFILES OF LIMB TRAJECTORIES CAN BE USED TO DISTINGUISH NORMAL FROM ABNORMAL MOVEMENT IN INFANTS AND YOUNG CHILDREN. FIRST, THE DEVELOPMENT OF UPPER EXTREMITY MOTOR CONTROL WILL BE INVESTIGATED BY USING KINEMATIC PROFILES TO STUDY VISUALLY-GUIDED REACHING TO A TOY TARGET. SECOND, KINEMATIC ANALYSIS OF LIMB TRAJECTORIES WILL BE COM ...

    SBIR Phase I 1988 Department of Health and Human Services
  8. MULTICHANNEL MICROELECTRODES FOR NEURAL RECORDING

    SBC: Network Instruments            Topic: N/A

    A MULTICHANNEL MICROELECTRODE THAT CAN MONITOR POTENTIALS FROM MANY NEARBY NEURONS SIMULTANEOUSLY WILL BE HIGHLY BENEFICIAL TO RESEARCHERS IN NEUROSCIENCE. SUCH A TOOL WILLALLOW HIGHLY RFFICIENT DATA COLLECTION AND THE STUDY OF NEURAL GROUP INTERACTIONS DURING ANIMAL BEHAVIOR. THE AIM OF THE PROPOSED RESEARCH IS TO DESIGN, DEVELOP AND EVALUATE A MULTICHANNEL MICROELECTRODE SYSTEM FOR MASS PRODUCTI ...

    SBIR Phase I 1988 Department of Health and Human Services
  9. MULTICHANNEL MICROELECTRODES FOR NEUROCHEMICAL SENSING MULTICHANNEL MICROELECTRODES FOR NEUROCHEMICAL SENSING

    SBC: Network Instruments            Topic: N/A

    A MULTICHANNEL MICROELECTRODE THAT MONITORS NEUROCHEMICAL CONCENTRATIONS FROM MANY NEARBY BRAIN SITES SIMULTANEOUSLY WILL BE HIGHLY BENEFICIAL TO BRAIN RESEARCHERS. SUCH A TOOLWILL ALLOW SCIENTISTS BOTH TO COLLECT DATA MORE EFFICIENTLY AND TO STUDY THE DYNAMICS OF NEUROCHEMICAL GRADIENTS DURING ANIMAL BEHAVIOR WITHIN ANY BRAIN STRUCTURE. THE AIM OF THE PROPOSED RESEARCH IS TO DESIGN, DEVELOP AND E ...

    SBIR Phase I 1988 Department of Health and Human Services
  10. AN EPIDEMIOLOGIC TOOL TO DETECT ANGINA PECTORIS IN BLACKS

    SBC: New England Research Institutes, Inc.            Topic: N/A

    ANGINA PECTORIS IS OFTEN CONSIDERED A MANIFESTATION OF CORONARY ARTERY ATHEROSCLEROSIS THAT IS ASSOCIATED WITH AN INCREASED MORTALITY RISK. OVERALL, CORONARY HEART DISEASE IS THE LEADING CAUSE OF MORBIDITY AND MORTALITY IN U.S. BLACKS. IN AN ATTEMPT TO STANDARDIZE THE DIAGNOSIS OF ANGINA PECTORIS IN EPIDEMIOLOGIC STUDIES, ROSE DEVELOPED A QUESTIONNAIRE FOR CARDIOVASCULAR FIELD SURVEYS WHICH HAS PR ...

    SBIR Phase I 1988 Department of Health and Human Services

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