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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Radikal Therapeutics is developing a novel small molecule therapy (R-801) for neonatal prematurity that triggers an endogenous cytoprotective defense and thereby blocks pulmonary inflammation and acute lung injury (ALI). R-801 is formed from the covalent fusion of 2 moieties with demonstrated tissue protective properties: 1) a mito-K+-ATP channel activating do ...

    SBIR Phase I 2013 Department of Health and Human Services
  2. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Radikal Therapeutics (RTX) is developing a novel cytoprotective agent (R-801) for the prevention of ischemia-reperfusion injury (IRI) following lung transplantation (LTX). In rodent models of severe redox injury, R-801profoundly reduces organ dysfunction, tissue infarction, and parenchymal inflammation. R- 801 is formed from the covalent fusion of 2 distinct m ...

    SBIR Phase I 2013 Department of Health and Human Services
  3. System for Targeted Estimation of Physiologic States to Facilitate SCAMPs in Inte

    SBC: Etiometry Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Sterling Point Research (SPR), in collaboration with Children's Hospital Boston (CHB), is proposing to develop a System for Targeted Estimation of Physiologic States (STEPS) that will enable the use of Standardized Clinical Assessment and Management Plans (SCAMPs) in the Intensive Care Unit. SCAMPs are a methodology for the systematic optimization of treat ...

    SBIR Phase I 2013 Department of Health and Human Services
  4. A Wearable Balance Booster- Stepping Closer to the Market

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): High volume mechanical ventilation (MV) induces a lethal pulmonary complication, termed ventilator induced lung injury (VILI), via the generation of toxic free radical and oxidant species that damage the alveolocapillary membrane, trigger pro-inflammatory gene expression, and induce pulmonary arterial hypertension and respiratory failure. To address this unm ...

    SBIR Phase I 2013 Department of Health and Human Services
  5. Decoy Peptides: Development of a Novel Therapeutic for Metastatic Cancer

    SBC: New England Research Institutes, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): There are two components to this study where human subjects are involved: development of content, and assessment of content. For the Development and Reel Review three focus groups will be held: 1) general audience; 2) minority, 3) parents specifically. We will conduct groups in these three categories to ensure we produce a film that is generally appealing, but ...

    SBIR Phase I 2013 Department of Health and Human Services
  6. DFG-out inhibitors of Abl-kinases to treat PML

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Radikal Therapeutics (RTX) is developing a novel pharmaceutical therapy for prematurity that targets a developmental deficiency in thioredoxin (Trx), a protein that serves as a central regulator of cellular reductant status. Trx is expressed t levels in the fetal lung too low to adequately counter the redox stress of extrauterine life, and i thus relatively def ...

    SBIR Phase I 2013 Department of Health and Human Services
  7. A Low-Cost, Portable Guidance System for Needle Biopsy

    SBC: Environment And Health Group, Inc.            Topic: NIMHD

    DESCRIPTION (provided by applicant): Over three-quarters of Hispanic women in the US are overweight or obese. High rates of excess body weight place these women at heightened risk for a variety of illnesses and health conditions, such as Type 2 diabetes, coronary heart disease, and osteoarthritis. Since children tend to share their parents' eating habits, it is no surprise that Hispanic child ...

    SBIR Phase I 2013 Department of Health and Human Services
  8. A Point of Care, Nucleic Acid Test for Chlamydia to Ensure Prompt Treatment of He

    SBC: Environment And Health Group, Inc.            Topic: NIMHD

    Title: Mobile Telecare for Underserved African-American Elders with Heart Failure Abstract Older adults who are dually eligible for Medicare and Medicaid are among the sickest and poorest individuals covered in either program. Although they have a significantly higher prevalence of chronic conditions, such as heart failure (HF) than all other Medicare beneficiaries, as few as 2% of dual eligible p ...

    SBIR Phase I 2013 Department of Health and Human Services
  9. Early detection of Alzheimer's (MCI stage): Analysis of plasma cell-free miRNA

    SBC: C4 Innovations, LLC            Topic: NIMH

    DESCRIPTION (provided by applicant): Service disengagement is one of the most pervasive and challenging problems currently facing America's mental health system. People in recovery have attributed their disengagement from care to having poor alliances withcare providers, including experiences of not being offered the opportunity to make decisions and collaborate in their own treatment. In res ...

    SBIR Phase I 2013 Department of Health and Human Services
  10. Developing a New Therapeutic for the Treatment of Invasive Aspergillosis

    SBC: COGITO HEALTH, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): Mental health disorders exact very high personal, social and economic costs in our country and around the world, presenting a significant public health challenge. Cogito has developed and deployed technology that listens to natural conversation and produces predictive accuracies of 70-90% with respect to various outcomes such as depression (Azarbayejani, Feast, ...

    SBIR Phase I 2013 Department of Health and Human Services

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