Award Data

DiscoveryofYellowFever VirusSpecificEpitopesforDevelopmentofanAccurateSerodiagnostic AssayAbstractAntibodies to many pathogenic viruses can be detected in bloodserum and or salivaAmong theseare many arbovirusesthat share endemic regions in the western hemisphere and in other parts of theworldThese include the related flaviviruses yellow fever virusYFVdengue virusDENVZika virusZIKVand West Nile vir ...

Systemic lupus erythematosusSLEis a complex autoimmune disease with a broad spectrum of clinical manifestations that affect several organsSLE affects millions of individualswith women and minorities disproportionately burdenedand is associated with significant morbidity and mortalityDespite considerable progress made towards understanding the disease and the identification of the central roles pla ...

ABSTRACT Next generation sequencingNGShas the potential to revolutionize how infectious disease is diagnosed and treatedenabling the detection of a wide variety of pathogens in a single testHoweverdespite the increasing adoption of molecular diagnostics in clinical microbiology labsNGS has not become widespread due to its costturnaround timeand the technical and computational expertise required to ...

Abstract Osteopenia is a highly common skeletal condition with accelerated loss of bone mass that leads to osteoporosisCharacterized by below normal bone mineral densityBMDosteopenia affectsmillion AmericansIf BMD loss is not mitigatedpatients become osteoporotic and are at increased risk of bone fracturesparticularly of the hip and spineSuch fractures decrease independent livingshorten life and i ...

Project SummaryAtantares Corpis seeking funding to develop a standardized foundation of thrombosis evaluationdriven through the principle of unification of standard laboratory and specialized hemostasis testinginclusive of a diversity of tests such as thromboelastographyTEGPT APTTmultiple electrode aggregometer etcwith the potential for iterative advance and multiplexingClinical realization of suc ...

Project Summary Abstract Physical Sciences IncPSIis continuing the pursuit of new clinical applications and advanced multimodal capabilities for its novel retinal imaging technology based on an adaptive optics line scanning ophthalmoscopeAO LSOThe Compact Adaptive Optics Retinal ImagerCAORIeliminates high speed scanning componentsreduces the clinical footprint compared to research adaptive optics ...

AbstractPrecision MembranesOverpeople died inin the U Salone due to septicemiaa blood stream infection capable of eliciting the life threatening condition known as sepsisRapid identification and effective treatment of septicemia are essential to prevent severe sepsis and overcome the alarming mortality rates observed todayCurrent diagnostics require a minimumhour blood culture prior to final ident ...

AbstractFor the PhaseSBIR projectCOMBiNATi is looking to prove the feasibility of an injection moldedk array digital PCR consumable for KRAS GR cancer rare mutation quantification analysisDigital PCRdPCRhas drawn attentions in both cancer genomic research and clinical research communities for its ability to detect rare eventshigh sensitivityless prone to inhibitionhigh specificityno need for an in ...

SUMMARY Effective management of obstructive pulmonary diseases characterized by thickenedhighly viscoelastic mucus represents a significant unmet medical needespecially in cystic fibrosisCFan inherited disease affecting approximatelyindividuals in the USIn CFgenetic dysfunction of the CFTRCystic Fibrosis Transmembrane Regulatortrans membrane channel results in impaired mucociliary transport and de ...

Abstract Diabetes is a complex multi factorial disease that diminishes the length and quality of life of affected individualsThe use of continuous glucose monitorsCGMcan be an invaluable management tool for patients afflicted by this chronic and costly diseaseHoweverdespite years of developmentcurrently available continuous glucose monitorsCGMsstill lack good accuracy and reliability for short ter ...