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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

Displaying 71 - 80 of 5003 results
  1. Humanized Anti-Renalase Antibodies for Unresectable Melanoma

    SBC: BESSOR PHARMA, LLC            Topic: 102

    Project Summary AbstractThis project brings together an experiencedintegrated project team with complementary expertise to advance a new approach to treating melanomas that cannot cured by surgery and have spread in the bodyThe project attacks a new targetrenalasean endogenous protein that can function as a survival factorwhich becomes overexpressed in melanomaand plays a role in suppressing the b ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Culture-free identification of pathogens common in endocarditis directly from patient specimens

    SBC: HELIXBIND INC.            Topic: NIAID

    PROJECT SUMMARY Infective EndocarditisIEis a life threatening disease that affects roughlyAmericans annuallyIE is characterized by microbial vegetations on the endocardial surface which induce serious heart damage and persistent bloodstream infectionsBSIsleading to sepsisLeft untreated IE is fatalAmong the criteria to establish IE and treat patients most effectivelyblood cultures are indispensable ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. CFI Pathogen Inactivation of Human Plasma Units

    SBC: APHIOS CORPORATION            Topic: NHLBI

    PROJECT SUMMARY The rapid spread of the Zika viruswhich can have a significant impact on neurological disorders in unborn fetuses and potentially adultsthe recent outbreak of the extremely virulent Ebola virusperiodic emergence of SARSrecurrent outbreaks of potentially pandemic strains of influenza such as H Nthe continuing epidemic of MERS and the worldwide AIDS epidemic have highlighted a persis ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Oxygen-Generating Dressing

    SBC: Theracell, Inc.            Topic: 600

    EquipmentThe equipment currently available at TheraCell includesBarnstead Reverse Osmosis Water Purification System Compressed Air system Laminar Flow Hood Fume Hood Oxygen plasma chamber Vacuum pumpsdry and oil Ultrasonic cleaner Laboratory balances Convection oven Forced Convection Oven Nuaire Incubator Vacuum oven Small autoclave Large volume cooled centrifuge with swing out rotor and buckets I ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Retinal eye-tracking for the prognosis and monitoring of multiple sclerosis

    SBC: C. Light Technologies, Inc.            Topic: NINDS

    Abstract The goal of this project is to validate an innovativehighly sensitive retinal eye tracking technologythe tracking scanning laser ophthalmoscopeTSLOas a prognostic and monitoring tool for neurodegenerative disordersnamely multiple sclerosisMSThe applications of effective treatments for multiple sclerosis are constrained bythe absence of methods for early detection andquantitativehighly sen ...

    STTR Phase I 2018 Department of Health and Human Services
  6. Less is More: Context-relevant views of EHRs

    SBC: Elimu Informatics Inc            Topic: NIA

    Project Summary We propose to refine and evaluate a system for automatically creating context relevant views of electronic health recordsEHROlder patientswith multiple conditionstend to have larger amounts of data in their EHRsThis creates an information overload problem for clinicians managing their carerequiring more time and effort to find the data they need for a particular task or contextMore ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Novel therapy for atopic dermatitis

    SBC: LARIX BIOSCIENCE LLC            Topic: NIAID

    Novel therapy for atopic dermatitis AbstractAtopic dermatitisADis a chronic inflammatory skin disorder that affects overmillion AmericansSevere AD results in skin damage that increases the risk for secondary infectionsMild AD is treated with topical anti pruritics and anti inflammatory steroidsModerate to severe ADhoweveroften requires systemic therapyCurrent therapiesincluding anti IgEare either ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and Therapeutics

    SBC: SAB Capra LLC            Topic: NIAID

    Project Summary A research plan is proposed to engineer goats that produce fully human immunoglobulinThese animals will be evaluated as a candidate platform system for production of both targeted therapeutic immunoglobulin as well as reagent antibodies for standards and controls of serological assays of human clinical samplesPrevious studies have demonstrated that ungulates such as cattle can prod ...

    STTR Phase I 2018 Department of Health and Human Services
  9. Development of methodologies for the analysis of FFPE tissues by CODEX for high-parameter imaging data collection

    SBC: Akoya Biosciences, Inc.            Topic: 400

    Project Summary Abstract Single cell technologies have contributed to the understanding of underlying order in heterogenous samplesproviding a platform to identify rare cell types with implications to human diseaseThese platforms are largely based on analyses of single cell suspensions and do not provide a spatial context to the findingsIt is becoming increasingly evident that the tissue architect ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. The Kappa Partial Agonist PPL-103 as a Potential Cocaine Abuse Pharmacotherapy

    SBC: PHOENIX PHARMALABS, INC.            Topic: NIDA

    Abstract Currentlyclinically used drug abuse medications exist for treatment of addiction to opiatesalcoholand nicotinebut not cocaineThe objective of the proposed project is to test the hypothesis that the partial kappa agonist PPLcan be effective as a pharmacotherapy for treatment of cocaine abuseBecause of chronic drug induced changes in the kappa opioid receptor systemkappa receptor directed c ...

    STTR Phase I 2018 Department of Health and Human Services

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