List

Project Summary Advances in genome miningand consequent realization of untapped microbial diversity has lead to renewed interest in natural productNPdiscoveryNPs are a rich source of therapeutic candidateswith a long history of successes in combating infectious diseasesand oncologyThe emergence of antibiotic resistant bacteria like Cdifficile and carbapenem resistant enterobacteiaceaeCREonly empha ...

SUMMARY The broadlong term goal of this project is to develop a pritelivir intravaginal ringIVRfor the treatment and pre exposure prophylaxis of genital herpesa common problem that affects more thanmillion AmericansRecurrences are common and may be painfulInfection is life longPritelivir is a promisinghelicase inhibitor that proved superior to existing therapies in Phaseclinical trialsbut whose cl ...

PROJECT SUMMARYAlcoholic liver diseaseALDincludes a broad range of progressive disease stagesfatty liveralcoholic steatohepatitisASHliver fibrosisliver cirrhosisand hepatocellular carcinomaIn spite of being one of the major causes of morbidity and mortality in the worldthere are currently no effective strategies that can preventtreat or monitor the progress of ALD owing primarily to lack of human ...

Metastasis is the most common cause of cancer related mortalityyet there are currently no therapeutic options that can be used to stop the spread of malignant cellsRecentlytwo members of the Transforming Growth Factorfamilythe secreted ligands Nodal and Bone Morphogenetic ProteinBMPhave been linked with increased metastasis in breast and other cancersThese cytokines activate stem cell programs in ...

SUMMARYABSTRACT Asthmatic bronchoconstriction and hypertensive vasoconstriction are extremely common disease states in which excessive contractile cellular forces directly contribute to the pathophysiologyExisting treatments for these diseaseswhich affectmillion andmillion Americansrespectivelyhave severe side effectsbecome desensitized over prolonged useor lack efficacy altogetherIn particularLAB ...

Project Summary Abstract G protein coupled receptorsGPCRsmediate most of our bodyandapos s physiological responses to hormonesneurotransmitters and environmental stimulantsThey are trans membrane proteins that are expressed in every type of cell in the body where their function is to detect molecules outside the cell and transmit signals across the membrane to activate cellular responsesThese prot ...

PROJECT SUMMARY ABSTRACT The goal of the current Phase I project is to developto clinical trial readinessand evaluate feasibility of a mobile ecological momentary intervention designed to improve social functioning in individuals with schizophreniaWhile effective treatments such as group based social skills training and computerized social cognition training are known to induce positive effects on ...

Project Summary Worldwidetens of millions are afflicted with chronic migraineCMa highly debilitating neurological disorderWhile abortive and preventative therapies existthere are still nearlymillion peopleM in the US alonewho do not respond adequately to these therapies and suffer from Intractable Chronic MigraineICMThose patients are highly disabled by their disease and are faced with a significa ...

Project Summary Abstract This Phase II project aims to develop an automated system for extracting mesenchymal stem cellsMSCsalso known as multipotent stromal cellsfrom adipose tissues for treating many serious diseasesincluding myocardial infarctiongraft versus host diseaseand a variety of autoimmune diseasesOverclinical trials to date have established the feasibilitysafetyand in some cases effica ...

AbstractCannabinoids are a class of natural products shown to treat a wide range of diseasesincluding epilepsyone of the most common neurological disordersEpilepsy affects people of all ageswith overmillion epileptics worldwide and overnew cases of epilepsy each year in the United States aloneEven with numerous anti epileptic drugsAEDavailableof patients have uncontrollable seizures that do not re ...