Award Data

PROJECT SUMMARY There is an enormous need for therapeutics to prevent and treat Alzheimer's disease (AD). Adult Hippocampal Neurogenesis (AHN) is critical for normal learning and memory, but it declines in patients with AD. Work in animal models has underscored the role of AHN in improving cognition in the face of AD pathology. Thus, restoring AHN has emerged as an attractive target for an AD ther ...

PROJECT SUMMARY Childhood (diffuse) interstitial lung diseases affects infants, children, and teens and manifests as dyspnea, hypoxemia, and respiratory compromise resulting in high morbidity and mortality or life-long sequelae for survivors. Despite improvements in the understanding of and interventions for pediatric diffuse lung disease in the past 15 years, the current standard-of-care for conf ...

The aging population in the US and globally has led to an urgent need for therapeutics to prevent and treat Alzheimer's disease (AD). Adult Hippocampal Neurogenesis (AHN) is critical for normal learning and memory and declines in patients with AD. Work in animal models has underscored the role of AHN in improving cognition in the face of AD pathology. Thus, restoring AHN has emerged as an attracti ...

Project Abstract In this Phase I SBIR project, ASTER Labs will develop and evaluate an innovative system to automatically and accurately detect Activities of Daily Living (ADL) performed by persons with Alzheimer’s disease and related dementias. It will address a current need to equip caregivers and health care providers, including physicians and cognitive rehabilitation therapists, with reliabl ...

PROJECT SUMMARY/ABSTRACT In the United States, the postpartum period is a critical time for both maternal and child health; the US maternal mortality rate is the highest among other developed, high-income countries. More than half of all maternal deaths occur postpartum, from one day to one year after birth.1-9 There are vast racial and ethnic disparities in maternal mortality and severe morbidity ...

Abstract Koronis Biomedical Technologies (KBT) and its collaborators propose to develop and fully validate a low-cost, developmentally appropriate, smartphone-based cognitive intervention for young children. The proposed intervention seeks to address the needs of families with young children identified with deficits in Executive Function (EF), a critical set of cognitive processes associated with ...

Abstract A 2019 study from the CDC estimated 812,000 children (age 17 or younger) were treated in U.S. emergency departments for concussion or Traumatic Brain Injury (TBI), alone or in combination with other injuries in 2014. Another recent study, which specifically focused on children’s sports and recreation-related TBIs found the number of related emergency department visits averaged more than ...

Project Summary/Abstract Proposed is a sleep monitoring system specifically designed for care providers of persons with Alzheimer’s disease and Alzheimer’s Disease Related Dementias (AD/ADRD) to monitor sleep disturbances and trends. Significance: Studies indicate that approximately 1 in 3 patients with AD/ADRD suffer from sleep and other nighttime disturbances such as insomnia and disruption ...

PROJECT SUMMARY/ABSTRACT More than 228,000 people in the United States will receive a lung cancer diagnosis this year. Only 14%-49% of early-stage patients survive at least 5 years after their diagnosis, and the survival rates fall below 5% for patients with advanced-stage IIIB or IV. Tumor recurrence after resection is a critical factor influencing these poor prognoses. If any cancerous tissue is ...

Project Summary/Abstract 30.3 million Americans are diabetic w/ 1.5 million new cases per year. Hypoglycemia negatively affects diabetics. The average type 1 diabetic experiences 2 symptomatic hypoglycemia episodes/week. Severe hypoglycemia (need for 3rd party assistance) results in 1.0 – 1.7 episodes per patient per year. Annually, 73% of insulin dependent type 2 diabetics experience hypoglycem ...