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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. An unique patient population for clinical trials against noise-induced hearing loss

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    AbstractNoise is the number one occupational and environmental hazardand noiseinduced hearing lossNIHLis one common form of sensorineural hearing deficitonly second to age related hearing lossCurrently no drug preventing NIHL is approved by the United States Food and Drug AdministrationFDAOne major challenge for the introduction of such interventions is the need to identify appropriate human popul ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A Unique Automated Bioreactor for Rearing Aseptic Mosquitoes from Larvae to Adults to Support Manufacture of Sanaria PfSPZ Products.

    SBC: SANARIA INC.            Topic: NIAID

    Project Summary AbstractThe annual estimated burden of malaria has increased toM clinical episodes anddeathsand annual losses of andgt $B of GDP to malaria in Africa aloneThe world needs a malaria vaccineSanaria s Plasmodium falciparum sporozoitePfSPZvaccines have protectedof subjects against controlled human malaria infectionCHMIin five clinical trials in the U SGermanyTanzaniaand Maliprotected a ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Manganese-peptide Countermeasures for Radiation Exposure

    SBC: BIOLOGICAL MIMETICS, INC.            Topic: NIAID

    The toxicity of ionizing radiationIRin diverse cell types is associated with a high susceptibility of the proteome to oxidative modificationProteome protection as a tactic for IR survival was recently applied to mice using a synthetic Mn peptide antioxidant complexMDPthat specifically prevents protein oxidation and preserves the activity of irradiated enzymesincluding those for cellular DNA repair ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Development of an Accessible, High-Precision Histology Procurement System

    SBC: AVONEAUX MEDICAL INSTITUTE, LLC            Topic: 400

    Project Summary Tissues contain multiple cell typesnervevasculatureepitheliumfibroblaststhat enable their specialized physiological functionsQuantitative molecular analysis of cells from histological slides is useful in developing a deeper understanding of fundamental pathophysiology and in generating effective clinical interventionsSeveral strategies were developed in the past to more precisely r ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Magnetically Enhanced Diffusion for Intra-Arterial Treatment of Acute Ischemic Stroke

    SBC: Pulse Therapeutics, Inc.            Topic: 101

    Acute ischemic strokeAISis the result of a blood clot in a cerebral arteryCurrentlyAIS remains a leading killer and the leading cause of long term disabilitywhich annually impacts nearlyAmericansBecause brain tissue rapidly diestime to reperfusion is critical in both preventing death and improving neurological outcomesWhile economic burden associated with ischemic stroke are high in the United Sta ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Design and directed evolution of an 'Edmanase' enzyme for high-throughput peptide sequencing

    SBC: ENCODIA INC            Topic: 400

    PROJECT SUMMARY ABSTRACT SignificanceNext generation sequencingNGShas has transformed the field of genomics and enabled broad adoption of the technology in biologicaltranslationaland most recently clinical researchThe proteomics equivalent to NGS has not yet been realizedAs suchthe goal of this proposal is to develop an innovative and highly scalable digital peptide sequencing platform to effectiv ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel Immunological Probiotic for Treating Inflammatory Bowel Disease

    SBC: Rise Therapeutics, LLC            Topic: 300

    Project Summary The goal of this project is to develop a novel probiotic based therapeutic for the treatment of inflammatory bowel diseaseIBDthat is ideal for long term maintenance treatmentOvermillion adults and children in the United States suffer from IBDan umbrella term encompassing two chronic inflammatory diseases of the gastrointestinal tractCrohnandapos s diseaseCDand ulcerative colitisUCI ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Microfluidic Device for Molecular Binding Assessment and Drug Discovery

    SBC: InnoScouting LLC            Topic: 400

    SUMMARY ABSTRACT The broad impact of this SBIR phase I project is to develop and commercialize a novel biophysical instrument that will greatly enhance researcherscapability to identify better drug candidates for molecular medicineSignificanceBiophysical analysis of molecular interactions is not only essential for disease related biomedical researchbut has also become increasingly popular for drug ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Rapid Test to Assist Therapy in Neonatal Sepsis and Necrotizing Enterocolitis

    SBC: PROTHERA BIOLOGICS, INC.            Topic: R

    The primary goal of this proposed research is to develop a rapid point of care test that assesses the risk of neonatal sepsisNSand or necrotizing enterocolitisNECin infants based on Inter alpha inhibitor proteinsIAIPlevels in bloodThe test is expected to be simpleuser friendlyportable and suitable for use in the NICUNS and NEC are associated with high mortality and morbidityincluding adverse neuro ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Therapeutic peptide for hepatocellular carcinoma

    SBC: Asclepix Therapeutics, Inc.            Topic: 102

    Therapeutic peptide for hepatocellular carcinomaNiranjan BPandeyPh DPIAleksander SPopelPh DCo IJordan JGreen Ph DCo I Phuoc TTran M DPh DPI of subcontract Project SummaryThere are very limited options currently available for the treatment of hepatocellular carcinomaHCCthe most common type of liver cancerHCClike most forms of canceris dependent on angiogenesisthe growth of blood vesselsThese and ot ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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