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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. The Development of a High-Throughput Assay to Screen Chemical Compounds in Human Pluripotent Stem Cell Derived Neural Cells

    SBC: ATHGHIN BIOTECHNOLOGY, INC.            Topic: 113

    DESCRIPTION provided by applicant The long term objective of this application is to provide a high throughput platform to test the effects of chemical exposure on human brain development In the US chemicals are not required for health or environmental safety testing before their incorporation in consumer products Over registered chemicals are in commerce most of which are used withou ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Clinical Translation of an Anti-Metastatic Antibody for Breast Cancer Therapy

    SBC: FOR-ROBIN, INC.            Topic: 102

    DESCRIPTION provided by applicant Translational studies are proposed to support the continued development of the JAA F antibody based therapy to address the critical need for a safe and effective treatment for metastatic breast cancer including triple negative breast cancers Building on the success of our Phase I project the overarching objectives of the Phase II application are to advanc ...

    STTR Phase II 2015 Department of Health and Human Services
  3. Calibrated Methods for Quantitative PET/CT Imaging Phase II

    SBC: Kitware, Inc.            Topic: 102

    DESCRIPTION provided by applicant The overall goal of this Phase II STTR proposal is to develop a PET CT imaging tool that will help accelerate the development of effective cancer therapies by improving the utility of oncology trials using PET imaging The growing cost time and complexity of clinical trials are driving patient and pharmaceutical company demand for more objective efficient a ...

    STTR Phase II 2015 Department of Health and Human Services
  4. Neuroimaging tools for presurgical brain mapping

    SBC: PRISM CLINICAL IMAGING, INC.            Topic: 102

    DESCRIPTION provided by applicant The goal of this project is to develop functional magnetic resonance imaging fMRI tools to assist the diagnosis and treatment of human patients with a brain tumor or other operable pathology The specific focus of this proposal is to produce a practical clinic ready suite of MR imaging methods analyses and display tools to solve the number one impediment to ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Axonal Transport HTS Platform for Neurodegeneration Drug Discovery

    SBC: Bellbrook Labs, LLC            Topic: 106

    DESCRIPTION provided by applicant Neurodegenerative diseases that affect motor neurons such as PD ALS and HD represent an enormous unmet medical need that is growing with the aging population Existing treatments have little or no effect on the course of disease and patients have to cope with the loss of brain and body function for the rest of their lives Defects in the transport of organell ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Automated Assessment of Leptomeningeal Collaterals on CT Angiograms

    SBC: Kitware, Inc.            Topic: 108

    DESCRIPTION provided by applicant The primary goal of this study is to develop an automated scoring system of leptomeningeal collaterals based on CT angiography CTA as a quantitative assessment of acute stroke Leptomeningeal collaterals provide an alternate path of blood flow in the setting of a proximal occlusion The presence and effectiveness of leptomeningeal collaterals i e andquot c ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. IMMEDIATE FIT USING INNOVATIVE TECHNOLOGY TRANSTIBIAL PROSTHESIS

    SBC: IFIT PROSTHETICS, LLC            Topic: NIA

    DESCRIPTION provided by applicant The goal of iFIT Prosthetics LLC r and its founder was to create and commercialize a modular immediate fit fully adjustable transtibial prosthesis system suitable for mass production using high strength polymer materials that are injection molded at a fraction of the cost of conventionally made prostheses This goal was achieved and now the aims of this P ...

    STTR Phase II 2015 Department of Health and Human Services
  8. A Universal Flu Vaccine Based on Conformationally Locked Soluble Headless HA

    SBC: AVATAR MEDICAL, LLC            Topic: NIAID

    DESCRIPTION provided by applicant An influenza pandemic remains an acute threat to world health and stockpiling a universally protective influenza vaccine provides a strong defense against this potential catastrophe The hemagglutinin HA protein is the primary target of humoral Ab responses to Influenza Vaccines based on full length HA give rise predominantly to strain specific Ab response ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Balancing Immunogenicity of a Tetravalent Live Attenuated Dengue Vaccine

    SBC: Codagenix Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Dengue virus DENV infections are the leading mosquito borne human viral diseases in the world with billion people at risk of infection The diseases caused by DENV range from a self limiting Dengue fever DF to the life threatening hemorrhagic DHF and capillary leak syndrome Dengue shock syndrome DSS DENV accounts for possibly million infectio ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Optimization of Supercritical Carbon Dioxide Based Virus Inactivation, Characterized by Protein Damage and Maintenance of Epitope Integrity in Vaccine Sterilization

    SBC: NOVASTERILIS            Topic: NIAID

    DESCRIPTION provided by applicant The process combining supercritical CO and co sterilants produces strong synergistic microbicidal effects in relatively mild conditions The mechanism of microbe inactivation is not well characterized but the disruption of lipid membranes and mild oxidative damage appear to be involved The process which is also highly efficient against viruses is considere ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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