List

DESCRIPTION provided by applicant Most drugs interact with protein molecules to elicit a cellular response Traditional drug discovery is a laborious and expensive experimental process so computational approaches to assess protein function and to accelerate the discovery process are in high demand Virtual drug screening and structure based drug design represent computational approaches that c ...

DESCRIPTION provided by applicant Osteoarthritis OA is a significant contributor to human morbidity and mortality with an economic burden exceeding $ billion annually in the United States Lubricin is a natural lubricant of the articular cartilage of the knee and the intraarticular administration of lubricin prevents OA progression following knee injury However the manufacture of lubrici ...

DESCRIPTION provided by applicant Respiratory infections with influenza viruses cause severe morbidity and mortality in humans and animals worldwide Importantly in humans the majority of morbidity and mortality following flu infection is seen in older individuals andgt year old Yet clear understanding of how aging impacts on innate immune responses and how to improve vaccine design ...

DESCRIPTION provided by applicant Development of novel lung cancer therapeutics targeting the DNA damage response Abstract Lung tissue is constantly exposed to a wide variety of inhaled chemical agents While the majority of these maybe innocuous those that damage DNA have severe consequences Thus the DNA damage response DDR and DNA repair in these tissues is extremely important The vast ...

DESCRIPTION provided by applicant Prostate cancer PCA is the most common non skin cancer and the second leading cause of cancer death in American men with over new cases diagnosed and over PCA deaths annually in the United States Ultrasound guided biopsy is the standard of care for confirming cancer typically following elevated PSA levels however it has been estimated that ...

DESCRIPTION provided by applicant Prostate cancer PCa is the No killer among male cancer patients The ultimate test is based on transrectal ultrasound guided needle biopsy and histological examination of fixed prostate tissues This conventional diagnostic procedure is invasive missing cases of cancer due to small sampling volume Moreover it leads to an overtreatment of patients du ...

DESCRIPTION provided by applicant Kinase inhibitors created a new paradigm in chemotherapy and are a major focus of new oncology drug development The Bcr Abl inhibitor imatinib was a breakthrough drug for chronic myelogenous leukemia with overwhelming early results however at least of patients are either intolerant resistant or experience recurrence within years and individual respo ...

DESCRIPTION provided by applicant The goal of this Phase I is to develop a prototype for a novel antiviral therapy directed towards Epstein Barr virus based on a novel post transcriptional regulatory mechanism called structurally interacting RNA or sxRNA We are pioneering a revolutionary antiviral approach that uses a viral encoded microRNA miRNA to create specificity even in infections in t ...

DESCRIPTION provided by applicant The CDC estimates that in the U S people aged years and older are living with HIV infection with approximately others infected but undiagnosed CDC Strict adherence to highly active combination anti retroviral therapy HAART cART prevents full blown AIDS However HAART cART fails to cure HIV infection as it has little ...

DESCRIPTION provided by applicant This project presents a novel strategy and technology platform to achieve durable spinal stabilization despite non fusion pseudoarthrosis The team proposes to develop novel nanotube enhanced micron porous interbody fusion devices IFDs and nanotube enhanced pedicle screws as fixation devices for spinal reconstruction The technology is expected to speed up a ...