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Myocardial infarctionsMIor heart attacksischemic strokesISand peripheral artery diseasePADtogether considered cardiovascular diseaseCVDare all commonly caused by the same underlying pathologyatherosclerosisMIs and ISs are the leading causes of death and disability worldwideAtherosclerosis is a progressive pathology that develops asymptomatically over the course of many years as inflammatory plaque ...

PROJECT SUMMARY Objectives: The first objective is to develop a computer-based cognitive training system for individuals in the early stages of Alzheimer’s Disease. The product, a home-based custom Virtual Reality (VR) system will be developed, targeting cognitive domains (processing speed, executive functions, attention, language, memory) as well as depression. The system will incorporate a nov ...

Magnetic resonance imagingMRIis a safenon ionizing diagnostic toolThe overall goal of this project is to arrive very close to the ultimate intrinsic signal to noise ratioUISNRfor a given MRI magnet field strength by combining innovations in very advanced transceiver technologyIn Phase Ia high performance head RF coil receiver array will be prototyped and SNR performance compared to an existing com ...

Project SummaryUltrasonic vocalizations (USVs) are known to reflect emotional processing, brain neurochemistry and brain function - key observations in animal model studies. Collecting and processing USV data is time-intensive, manual, and costly. Most importantly, it limits researchers’ ability to employ fully effective, and nuanced experimental designs, and is a barrier to entry for other rese ...

PhenylketonuriaPKUis a genetic disorder of metabolism characterized by a pathological elevation of phenylalaninePhein the body stemming from a dysfunctional phenylalanine hydroxylase enzymePAHThe resulting high concentrations of Phexcan result in severe intellectual disabilitybehavioral problemsand neurological deficitse gseizuresStrict control of dietary Phe is the primary treatment for PKU curre ...

Filoviruses, consisting of two major virus families including the ebolaviruses and marburgviruses (MARV and RAVV), cause periodic outbreaks of severe viral hemorrhagic fever with mortality rates as high as 90%. Since it is difficult to predict the species that would dominate future outbreaks, development of broadly protective therapeutics to prevent and manage future filovirus outbreaks is of high ...

Project Summary Laparoscopic surgeryreferred to as minimally invasive surgeryis a surgical technique in which operations in the abdominal or pelvic cavities are performed through smallmmincisionsIt is now considered the standard of care for many procedures on female pelvic floor which account for approximatelymillion cases per year in the U SThe laparoscopic technique includes traditional minimall ...

Project Summary Bacillus anthracis (Ba) is a Gram-positive spore forming bacterium that is listed as an agent of highest concern (Category A) by NIAID and CDC. Ba is easy to grow, and its spores can be formulated into highly stable powder form and disseminated as aerosol or used to contaminate food or water. In 2001, letters laced with powdered anthrax spores were mailed to several US politicians. ...

PROJECT SUMMARY We have developed an antibody like HIVentry inhibitoreCDIgcomposed of the first two domains of CDfused to an antibody Fc domain and a short tyrosine sulfated CCRmimetic peptideeCDIg has properties that make it an exceptionally promising tool in the fight against the HIVpandemicSpecificallyit is broader than any broadly neutralizing antibodybNAbat least as potent at neutralization a ...

Abstract Summary In this SBIRwe propose to validate our handcrafted image analysis algorithm for auto detecting Mycobacterium tuberculosisMTBin a digitized sputum smearOnce validated in a blinded study against manual microscopy and culturethe gold standardwe will try to improve our handcrafted algorithm by integratingwhere appropriatedeep learning approachesvia Convolutional Neural NetworksCNNOur ...