Award Data

Additive Manufacturing (AM) will play a large role in the development for NASArsquo;s next generation of space flight systems. However, without a deeper understanding of various additive processes available, it is difficult to use the technologies reliably. In order to predict the results for dimensional accuracy, microstructure formation, and defect initiation points, FormAlloy and New Mexico Sta ...

For long duration space missions beyond LEO there is a wealth of COTS hardware that could potentially be implemented for non-critical tasks within heavily shielded spacecraft cabins. To employ COTS systems for such missions, we propose to use a simulation/experimental/statistical approach for risk acceptance Radiation Hardness Assurance (RHA) suitable for Cis-Lunar and Cis-Mars missions. The simul ...

Project Summary The work described in the application is necessary for furthering the development of a new therapeutic for treating Gram-positive infections. Preliminary in vitro and in vivo activity studies of novel analogs of mutacin 1140 suggest that they hold great promise as an antimicrobial product for clinical use. Mutacin 1140 is produced by the bacterium Streptococcus mutans JH1140 and th ...

As the orbital space around the earth gets more and more crowded with civilian and military reconnaissance, weather, tracking, communication, and navigation satellites - civilian and military users become increasingly dependent on the services provided by these spacecraft. This situation increases the possibility of offense actions against some or all of these spacecraft. The possibility calls for ...

ABSTRACTChronic Obstructive Pulmonary Disease (COPD) is the third leading cause of hospitalization in the US. Exacerbations - a worsening or “flare up” of symptoms - cause most COPD hospitalizations. Since most exacerbations can be treated with changes of inhalers and/or oral medications, at-home detection of lung function deterioration may facilitate earlier intervention and help delay or pre ...

ABSTRACT Pulmonary hypertension (PH) is a highly debilitating disease that affects about 1% of the global population, which increases up to 10% in individuals aged more than 65 years. The life expectancy for these patients is less than 10 years after diagnosis, and no specific drugs are available for pharmacologic treatment. Despite the introduction PDE5, prostacyclin analogs, and endothelin antag ...

Abstract Rejuvenation Technologies Inc. (RTI) aims to prevent liver fibrosis in alcoholic hepatitis (AH) by enhancing liver regenerative capacity. AH is an acute form of alcoholic liver disease with mortality of up to 50% within 1 month of presentation. Most AH patients exhibit advanced fibrosis/cirrhosis, which contributes to acute-on-chronic liver failure. RTI will ameliorate/prevent this fibros ...

Forward-looking infrared seekers are the preferred guidance system for current and future hypersonic interceptors. Seeker performance is limited by the infrared window’s ability to survive and image in a high-Mach, endo-atmospheric environment where heating rates can exceed 80 W/cm². Window materials primarily fail because of thermal shock, but can also experience issues due to absorption/emiss ...

Carbon-carbon (C-C) composites are used in the fabrication of aeroshells and thermal protection systems (TPS) in hypersonic and atmospheric reentry applications because they maintain their strength at elevated temperatures and have desirable thermal conductivity properties. Although these materials have been used in mission-critical components for decades, the effects of variations in processing m ...

Laser guide stars (LGS) are artificial sources of light produced by laser-induced fluorescence from sodium atoms in the mesosphere between 85 km and 100 km altitude. The fluorescence can be detected on the ground with a telescope and used as a reference for compensating atmospheric aberrations in astronomical and space observations in conjunction with an adaptive optics system. Sodium LGS are vita ...