Award Data

Plastics are indispensable materials for the modern life and global economy, but current practices in the generation and disposal of commodity plastics are largely unsustainable and causing severe worldwide plastics pollution and enormous materials' energy and value losses to the economy. In particular, plastics are a material of choice in packaging applications but they are currently designed for ...

The problem/situation that is being addressed concerns the development of near infrared ultrafast interference coatings(IC) for high average power femtosecond lasers that will meet the specifications of the DoE solicitation: “broad-bandwidth, laser damage threshold of 0.5 J/cm2 (1 ps), engineered using a process that is scalable to large areas.” Advances in compact high gradient laser-driven p ...

The problem being addressed is the development of high intensity ultrashort pulse lasers, in recognition that today’s ultra-high intensity lasers are limited to repetition rates of < 10 Hz. Technical solutions are sought to enable the generation of high energy (joule-level) laser pulses that can be focused to highly relativistic intensity at high repetition rates (100-1000 Hz). The proposed proj ...

The metabolic syndrome (MetS) is a cluster of factors that increases the risks for cardiovascular disease, type 2 diabetes mellitus, and mortality, and currently affects andgt; 40% of US adults. MetS is associated with endothelial dysfunction, decreased circulating endothelial progenitor cells (EPCs), and a pro-inflammatory state. We have made the exciting discovery that therapy with allogeneic me ...

The broader impact/commercial potential of this STTR project is in the reduction of healthcare-associated infections (HAIs) by proactively responding to data from novel sensors. In addition, the technology being developed in this project can also help measure airborne particle concentrations in other environments. The successful completion of this proposal will result in improved public health fro ...

This NASA sponsored STTR project will investigate methods for close-out of large, liquid rocket engine, nickel or stainless steel nozzle, coolant channels utilizing robotic laser and pulsed-arc additive manufacturing (AM)methods. Structural jacket to coolant channel land area interface strength will be quantified and metallurgical characterization completed.Process optimizations will be conducted ...

To address the urgent need for 3D flash-lidar technology for landing on solar system bodies and for spacecraft rendezvous and docking with satellites, an effort is proposed to fabricate, characterize, and test a versatile, high-sensitivity InGaAs APD 3D flash lidar and to advance the technology-readiness level (TRL) of lidar technologies suitable for NASA mission requirements. Leveraging an existi ...

Abstract. LEXEO Therapeutics, LLC, is an early stage biotechnology company focused on using gene therapy technologies to protect vulnerable organs from oxidant stress. LEX01, the 1st LEXEO product, is a 1st in class, next generation gene therapy treatment for alpha 1-antitrypsin (AAT) deficiency, an autosomal recessive hereditary disorder associated with low serum levels of AAT. AAT (SERPINA1), a ...

This project will provide state-of-the-art predictive capabilities for simulating systems central to advancing the U.S. Army’s modernization priorities related to long-range precision fires and future vertical lift platforms. The goals of the project are to: (1) Produce geometry and meshing technologies that support the modeling and discretization techniques needed to explicitly track evolving/i ...

The objective of the Phase I proposal is to investigate the application of controlled cavitation cleaning technology in conjunction with gecko-inspired mechanical adhesion and soft elastomeric applicators for use in non-intrusive EOD operations. This investigation requires the proof-of-concept testing and validation of a controlled cavitation cleaning mechanism, and a soft robotic gecko-inspired m ...