Award Data

Abstract Cardiovascular Implantable Electronic Devices (CIEDs) like a Permanent Pacemaker or Implantable Defibrillator are implanted in over 3 million Americans, with the average age of implantation in the 60s, 40% ≥ 70 years old, and 28% ≥ 80 years old. When a patient presents to the Emergency Department (ED) with an unknown CIED, reprogramming of the device is often necessary for their treat ...

PROJECT SUMMARY ABSTRACTSystemic lupus erythematosusSLEis a multifaceted autoimmune disease characterized by immune dysregulationdisabling symptoms and progressive organ damageRecognition and early treatment to prevent tissue and organ damage is challengingas signs and symptoms of high disease activity and clinical disease flare are captured after their occurrenceDespite clinical instruments of di ...

PROJECT SUMMARY Of the 4 million babies born in the US each year, 120,000 (3%) have a complex birth defect. Some defects, such as spina bifida, warrant in utero interventions to improve fetal outcomes. Spina bifida is a condition where there is incomplete closing of the backbone and membranes around the spinal cord. Texas Children’s Hospital has pioneered a fetoscopic method to address spina bif ...

PROJECT SUMMARY We have developed an antibody like HIVentry inhibitoreCDIgcomposed of the first two domains of CDfused to an antibody Fc domain and a short tyrosine sulfated CCRmimetic peptideeCDIg has properties that make it an exceptionally promising tool in the fight against the HIVpandemicSpecificallyit is broader than any broadly neutralizing antibodybNAbat least as potent at neutralization a ...

PROJECT SUMMARYThe overall goal of this SBIR Phase II proposal is to refine and evaluate advanced quantitative magnetic resonance imaging (MRI) phantoms that mimic the simultaneous presence of fat, iron and fibrosis. Fat, iron and fibrosis are three principal histological coexisting features of many important disease states. Phantoms are highly controlled test objects that accurately reflect tissu ...

Cigarette smoking is the leading cause of mortality in the U Sresulting in overdeaths every year and costing more than $billion in loss of productivitySmoking is also the leading cause of cancer and of deaths from cancerAlthough the prevalence of smoking has declined over the pastyearslarge disparities in tobacco use remain across a number of groupsLatino a smokers represent a major health dispari ...

Project Summary This project proposes further development of a computational discovery platform shown to quantifiably identify and prioritize both targets and compounds for therapeutic intervention, which will accelerate the development of newer, more effective drugs with fewer side-effects. This platform is based on a novel fusion of two state of the art computational approaches (phenolog mapping ...

Abstract SignificanceAlthough patient simulators have demonstrated improved learning outcomes in medical trainingthere is a significant lack of realismThusthey do not effectively provoke a realistic emotional response in traineesThis significantly limits their educational value to the emergency medical serviceEMStraining agenciesas doesin the case of mannequinstheir costreliance on electricityand ...

Pathological cardiac remodeling constitutes a common pathway to heart failure in diseaseDespite current pharmacologic therapy and other advances that attenuate remodelingmortality due to heart failure remains highNewmore effective therapeutic options are desperately needed in an increasing patient population to improve both the survival and quality of life for patients with or susceptible to heart ...

PROJECT SUMMARY Gonorrhea is caused by the bacterium Neisseria gonorrhoeae and is the second most reported sexually transmitted infectionSTIin the worldIf left untreatedcomplications may include pelvic inflammatory diseasenewborn blindnessinfertility and increased risk of infection by other STDsincluding HIVThe Centers for Disease Control and PreventionCDCestimates thatnew gonococcal infections oc ...