Award Data

We will develop a new construction method for receiver coils for magnetic resonance imaging (MRI) of the human breast. These coils will be custom-shaped to individual patients in a quick, economical, and comfortable manner. Since each structure fits the individual patient closely, the coil system permits quantitatively repeatable imaging with accurately reproducible geometry. The structure for sur ...

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Intrapartum fetal infection by herpes simplex virus (HSV) is invariably symptomatic and often times fatal. Infection is usually associated with an active maternal genital infection with virus shedding at the time of delivery. Current recommendations call for weekly culturing of cervico/vaginal specimens to detect infectious virus. If a positive culture appears, caesarean rather than vaginal delive ...

RESEARCHERS HAVE DEVELOPED AN ULTRASENSITIVE QUANTITATION SYSTEM TO BE USED WITH A LARGE FAMILY OF ISOTOPES. THIS SYSTEM SUPPORTS LABEL MULTIPLEXING; MANY CO-RESIDENT ISOTOPES IN THE FAMILY CAN BE QUANTITATED SIMULTANEOUSLY, ALLOWING EITHER THE POOLING OF LABELED SAMPLES OR THE POOLING OF DISTINCTLY LABELED PROBE REAGENTS FOR MULTIPLE TARGETS. THE RESEARCH ADDS TWO-DIMENSIONAL (2D) SPATIAL RESOLUT ...

The scattering of neutrons permits to obtain structural information about diverse biological materials and processes. The impact of new intense sources of cold neutrons may revolutionize this field because it permits real-time, in vivo neutron microscopy. Featuring spatial resolution better than optical microscopy and excellent contrast, neutron microscopy provides a new imaging technique of high ...

We have developed an ultrasensitive quantitation system which can be used with a large family of isotopes. This system supports label multiplexing; many co-resident isotopes in the family can be quantitated simultaneously. This process allows either the pooling of labeled samples or the pooling of distinctly labeled probe reagents for multiple targets. The research will add two dimensional (2D) sp ...

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Retroviruses are universally recognized as human and animal pathogens that induce severe diseases. Because of their remarkable high frequency of genetic recombination retroviral, genomes result in a high level of polymorphisms. Such plasticity originates variants that are resistant to drugs or vaccines. The current treatments for retroviral infection are not effective because they do not inactivat ...

Contamination and accumulation of xenobiotics (i. e., environmental toxins, chemical carcinogens, mutagens) in critical domestic and industrial water sources and natural reservoirs pose a significant health risk to humans and animals. While conventional methods to detect the presence of xenobiotics are available, they are not sensitive, they have to be complemented with other assays, and they are ...