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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Recombinant Outer Membrane Vesicles as a Novel Adjuvant for a Malaria Vaccine

    SBC: VERSATOPE THERAPEUTICS, INC.            Topic: NIAID

    Plasmodium falciparum is the most fatal species of the malaria protozoan parasite infecting humansThe ability to control disease or outbreaks of Pfalciparum malaria with a vaccine has eluded investigators for decadesInnovative adjuvants for malaria vaccines are urgently needed to provide long lasting immune responses and high levels of inhibitory antibodiesWe propose to develop a novel malaria vac ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. The purpose of this contract is to develop imprinted polymer resins for the purification of HIV envelope vaccine candidates

    SBC: Zymeron Corporation            Topic: NIAID

    There currently lack diagnostic tools with necessary sensitivity for use in the elimination and post elimination efforts for malaria and other Neglected Tropical DiseasesNTDsMicroscopy and rapid diagnostic testsRDTshave been largely adequate for malaria control and case management but lack the sensitivity to detect low density infectionsAsymptomatic individuals with chronic infection remain reserv ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. SBIR Topic 089, Phase II, In-bore Defibrillation for Invasive MRI Cardiology Procedures

    SBC: PINMED, INC.            Topic: NHLBI

    The goal of the project is to develop an external cardiac defibrillator system for operation inside the MRI borePhase I would develop and test a working prototype in vivoPhase II would further develop the system and complete regulatory development to allow clinical testing in patients

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. SBIR Topic 105, Phase I, Reagent Development for Small Cell Number ChIC-seq

    SBC: AlphaThera            Topic: NHLBI

    The project goal is to develop reagents that can be used for mapping genome wide epigenetic changes during normal development and disease process in rare primary and patient cellsBecause conjugating proteins could result in inactivation of the proteinsit will be important to achieve efficient conjugation between antibodies and MNase while reserving the activities of both

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. SBIR Topic 104, Fast-track, Tapered Guidewires for Transcatheter Electrosurgery

    SBC: TRANSMURAL SYSTEMS LLC            Topic: NHLBI

    The goals are to develop and commercialize specific tools to simplify transcaval access to the aortaThe tools are a tapered guidewire and a connector switch to a common electrosurgery generatorThese will greatly simplify transcaval access proceduresreducing the required operator skillmaking the procedure more accessible to a wider array of patients and operatorsand reduce the cost of the procedure

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. SBIR TOPIC 096: Novel Biodegradable Metal Stents for Neonatal Aortic Coarctation

    SBC: PediaStent LLC            Topic: NHLBI

    Most stents used to repair congenital heart lesions only need to serve as temporary scaffoldingsBecause pediatric patients have growing cardiovascular structuresthere is great interest in use of bioresorbable stentsBRSfor the treatment of coarctation of the aorta in neonatesA pediatric bioresorbable stent would allow thousands of infants each year to avoid the morbidity and mortality of more invas ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. SBIR TOPIC 096:Novel Biodegradable Stents for Neonatal Aortic Coarctation

    SBC: 480 Biomedical Inc.            Topic: NHLBI

    Aortic coarctation is a common congenital heart condition that is usually recognized during the neonatal period early after birth The usual treatment is open surgery Non surgical catheter based stent therapy is not available to treat neonatal aortic coarctation because children outgrow commercially available metallic stents Absorbable stents might revolutionize the treatment of aortic coarctation ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. SBIR Topic 103, Fast-track, Devices for Transcatheter Surgery

    SBC: TRANSMURAL SYSTEMS LLC            Topic: NHLBI

    The objective of this contract is to design a series of prototype transcatheter devices that will enable a wide range of novel transcatheter procedures for both adult and pediatric structural heart patientsThere is an unmet need for a suite of tools that will enable a wide range of novel but attainable non surgical interventional cardiovascular procedureswhich the contractor will develop and testT ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Topic 372: Development of the Fully Humanized 9-in-9-out Rat Drug Metabolism-CYP450 Model, Using the Active Genetic: Gene Drive Technology

    SBC: SYNBAL, INC.            Topic: NCI

    In this Fast track SBIR grant we aim, by the end of Phase II, to prepare and commercialize a fully humanized rat with Knock-out of many rat drug metabolism related CYP450's (9-in-9-out Rat Drug Metabolism-CYP450 Model) and Knock-in of the human counterpart. IN PHASE I we will develop an Active Genes: Gene Drive (AG:GD) rat - a rat with a properly configured Cas9 to power Active Genetics (AG); AND, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Topic 368: Biotherapy of Brain Tumors by Radioiodinated SapC-DOPS Nanovesicles

    SBC: Molecular Targeting Technologies, Inc.            Topic: NCI

    There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health

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