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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of P2X3 Ion Channel MAbs for the Treatment of Pain

    SBC: INTEGRAL MOLECULAR, INC            Topic: 100

    DESCRIPTION provided by applicant Acute and chronic pain resulting from injury surgery or disease afflicts andgt million Americans each year having a severe impact on mood mental health and quality of life and costing the U S approximately $ billion in economic costs annually For many patients treatment options provide inadequate relief because of the shortcomings of available th ...

    SBIR Phase II 2014 Department of Health and Human Services
  2. Active Fine Gauge Spinal Needle with CSF Sensing to Minimize PDPH and Dura Damage

    SBC: ACTUATED MEDICAL, INC.            Topic: 300

    DESCRIPTION provided by applicant In this NIH SBIR Phase II Actuated Medical Inc will finalize and clinically test the andquot Active Fine Gauge Spinal Needle with CSF Sensing to Minimize PDPH and Dura Damage andquot Phase I achieved all Specific Aims and demonstrated that the Smooth Insertion Spinal SIS System provided greater control for the clinician by reducing the buckling of G tra ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. BioPrism- An Optical Chromatograph

    SBC: OPTOFLUIDICS, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant Optofluidics Inc proposes to develop a near field optical chromatograph the BioPrism and apply it to the characterization of particle coating stability in nanomedicine According to clinicaltrials gov about of all clinical trials involv nanoparticles and the National Science Foundation has predicted that nearly half of future pharmaceuticals will have s ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Selective inhibitors of ubiquitin E3 ligase to treat high cholesterol

    SBC: Progenra, Inc            Topic: NIEHS

    DESCRIPTION provided by applicant Hypercholesterolemia is a major risk factor in cardiovascular diseases it is estimated that andgt million individuals in the U S or one sixth of the adult population have high total cholesterol and thus twice the risk of heart disease compared to those with optimal cholesterol levels While statins are widely prescribed for cholesterol lowering their se ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Novel molecular therapeutics for cystic fibrosis

    SBC: Progenra, Inc            Topic: NHLBI

    DESCRIPTION provided by applicant Cystic fibrosis CF leads to chronic illness disability and early death Recurrent pulmonary infections are lethal owing to growth of bacteria and other microorganisms in the abnormally viscous mucus Antibiotics mucolytics and anti inflammatory agents are useful only in treating some CF effects Recently however ivacaftor a k a VX or Kalydeco w ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Technology Application to Enhance Discharge Referral Decision Support

    SBC: RIGHTCARE SOLUTIONS, INC.            Topic: 600

    DESCRIPTION provided by applicant Decreasing readmissions through better discharge planning DP and transitional care is a national healthcare priority RightCare Solutions has leveraged over years of interdisciplinary academic research led by a nurse researcher and through our highly successful phase one SBIR grant demonstrated market value for the D S product and the technical expertise ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Preclinical testing of the splice modulating oligonucleotide LSP-GR1

    SBC: LifeSplice Pharma            Topic: 106

    DESCRIPTION provided by applicant AMPA glutamate receptors mediate the majority of fast excitatory neurotransmission in the central nervous system Four AMPA receptor subunits exist GluA GluA with functional channels containing various combinations of these four subunits Dysregulation of AMPA receptor expression has been reported in many neurological disorders including amyotrophic latera ...

    SBIR Phase II 2014 Department of Health and Human Services
  8. Biofuel Production from Grease Trap Waste

    SBC: Environmental Fuel Research, LLC            Topic: F

    Environmental Fuel Research, LLC, proposes to commercialize a grease trap waste to biofuel process based on process research from Drexel University. Grease trap waste is dirty and low-value material produced by the food service industry that is high in lipids that can be converted to biodiesel. The quantity of grease trap waste in the United States could produce one-half billion gallons of biodies ...

    SBIR Phase I 2014 Environmental Protection Agency
  9. Calculation of Effective Material Strengths for 3D Woven Hybrid Preforms and Composites

    SBC: MATERIALS RESEARCH & DESIGN INC            Topic: H701

    The design concepts being considered for Heatshield for Extreme Entry Environment Technology (HEEET) rely on the use of 3D woven carbon fiber preforms. Therefore, there is a need to be able to predict the properties and performance of a woven material. Validation of predictive modeling tools would allow for the use of these tools to design and optimize the 3D weaves, significantly reducing the c ...

    SBIR Phase II 2014 National Aeronautics and Space Administration
  10. Integration of Complex Geometry, 3D Woven Preforms via Innovative Stitching Technique

    SBC: T.E.A.M., INC.            Topic: H701

    Thick, 3D woven carbon/phenolic composites offer potential improvement over legacy thermal protection systems (TPS) for re-entry vehicle heat shield applications. However due to the scale and complexity of typical re-entry vehicle structures, it is likely that multiple 3D woven panels would need to laid up to create the overall heat shield, creating a potential weak spots at the panel joints. ...

    SBIR Phase I 2014 National Aeronautics and Space Administration

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