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Project Summary The goal of the project is to develop new algorithms and computer codes based on the continuous fast multipole method that will dramatically decrease the computational complexity of large scale modeling of redox processes and other bioand photo chemical reactions accompanying metabolic pathways of drug moleculesRedox processes are at the heart of various biological functionsincludi ...

ABSTRACT Mitral regurgitationMRis the most common type of valvular heart disease in patients over the age ofyears in the USDespite the prevalence of MR in the elderly populationhoweveralmost half of patients identified with moderatesevere MR are turned down for traditional open heart surgery due to co morbiditiesMitraClipMCis a recent percutaneous approach to treat MR by placement of MC in the cen ...

Overof theindividuals who survive a stroke each year have persistent movement impairmentsIntensive rehabilitation could reduce their impairmentsbut access to such therapy is limitedHome therapy could supplement time with a therapistbut the current standard of care is simply providing individuals printed sheets of exercisesan approach that is not motivating and often not effectiveTechnological solu ...

Multiple myeloma is the second most common hematological malignancy and remains incurablewithof patients surviving less thanyearsPatient relapse is inevitable despite an increase in therapeutic optionshighlighting the significant need for predictive biomarkers that can rapidly and accurately determine tumor drug susceptibility to direct utilization of optimal therapiesWe will apply Travera s mecha ...

Consumer behavior throughout the world points to a high level of dissatisfaction with currently available contraceptive methodsAlmost a third of American women discontinue using hormonal methods of birth control within the first yearwhileof men discontinue using condoms within the same timelineConsumers are not satisfied with either the continual methodshormonalor the on demand optionsuch as condo ...

Project SummaryThere is a critical need for improved contraceptive methods in the U Sand worldwideNearly half of all pregnancies in the U Sare unintendedNot surprisinglythe majority of unintended pregnancies occur in women who are non users of contraceptionAlthough there are diverse reasons for non usemany women have a strong aversion to using exogenous hormonesdue to both real and perceived side ...

7. PROJECT SUMMARY Title: Development of a Next Generation Visual Performance Assessment System for Rodents Visual behavior abnormalities not only link directly to the retinal pathology and visual pathway disorders, but also associate with many neurodegenerative brain conditions, particularly with Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury. The optomotor reflex (OMR) ...

Project Summary The global contraceptives market was valued at $billion inand is expected to grow at a CAGR offromtoto reach an estimated value of $billion inThe contraceptive market consists of short term methods such as condoms and oral contraceptionlong term methods including implants and IUDsand permanent methods such as tubal ligations and vasectomiesEppin Pharmaandapos s product has a unique ...

Project Summary This Phase II SBIR project will develop, optimize, test, commercialize, and take to market an inhalation chamber that mimics the e-cigarette technology being used by human users, and being popularized by e- cigarette manufacturers and advertisers. E-cigarette use and abuse is a major public health concern, but little is known about the biology underlying e-cigarette use and negativ ...

PROJECT SUMMARY / ABSTRACT Every year, 50,000 very low birth weight (VLBW, andlt;1,500 g) infants are born in the U.S. The use of surfactant dramatically decreases morbidity and mortality due to respiratory distress syndrome (RDS) in VLBW infants. Current standards for surfactant administration require the infant to be intubated, so that surfactant can be delivered to the trachea and lungs. Intuba ...