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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. NON-NATURAL AMINO ACIDS IN PEPTIDE DRUG DEVELOPMENT

    SBC: ARGOLYN BIOSCIENCE, INC.            Topic: N/A

    Argolyn Bioscience Inc. is an early stage biotechnology company that creates novel peptide drugs and diagnostics with greatly improved intrinsic pharmaceutical properties through substitution of non-natural amino acid analogues for arginine (Arg) or lysine (Lys). In proof-of concept studies thus far, application of the Argolyn technology to peptides of therapeutic interest has resulted in dramatic ...

    STTR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  2. Isotopically Labeled Nucleotides for Biomolecular NMR

    SBC: CASSIA, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of the proposed research is to scale up the production and manufacture of high-value ribonucleoside triphosphates containing stable isotope labels. The use for these products is in biomolecular studies of RNA structure using Nuclear Magnetic Resonance (NMR) spectroscopy. The market for these products is structural biology groups in academic and industr ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  3. N/A

    SBC: IBIS BIOSCIENCES, INC.            Topic: N/A

    N/A

    STTR Phase I 2000 Department of Health and Human ServicesNational Institutes of Health
  4. Phenotyping All Genes of S. cerevisiae

    SBC: BIOLOG, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this project is to further develop, miniaturize, and extend the new Phenotype MicroArray (PM) platform technology (1-3) and then utilize this improved technology to genomically analyze biological pathways and gene function in the model eucaryotic microorganism Saccharomyces cerevisiae. The steps will be 1) development of miniaturized, more eff ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  5. ANTIIDIOTYPE MAB:AN ANTIANGIOGENIC /ANTIMETASTATIC AGENT

    SBC: PIVOTAL BIOSCIENCES            Topic: N/A

    Angiogenesis (new blood vessel formation) is a critical step for tumor growth and metastasis, and its inhibition is currently the most promising approach for cancer therapy. Contortrostatin (ON) is a protein isolated from southern copperhead snake venom, which has been shown to effectively block angiogenesis, as well as metastasis. The potent inhibitory effect of CN on cancer ...

    STTR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  6. PROTOTYPE FABRICATION OF A CELL MIGRATION SENSOR

    SBC: RAINMAKER TECHNOLOGY            Topic: N/A

    DESCRIPTION (provided by applicant): There is a growing need for the development of a system to measure cell transmigration in a dynamic environment. Such a system would help to monitor the cellular immune response in patients with immunodeficiencies, diabetes, autoimmune diseases, or under chemotherapy. It can be an alternative for experimental animal models in inflammation and cancer biology c ...

    STTR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  7. Evolutionary Approaches for synthetic Library Design

    SBC: DNA Twopointo Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Directed evolution has been widely employed to enhance protein structural stability and activity, expand functionality and alter specificity. We propose a novel approach for generating libraries of variant genes that takes advantage of the evolutionary history of a gene family by generating a combinatorial library incorporating amino acid replacements inferred ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  8. Numerical Tools for Predicting Drug Dissolution Profiles

    SBC: RES Group, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): This STTR Phase I proposal describes the development of a modeling framework that combines a mesoscopic model for hydrodynamics with dissolution kinetic models in order to accurately describe the dissolution behavior of drugs. The complexities of the drug dissolution problem have led to the development of empirical methodologies being the widespread practice in ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  9. N/A

    SBC: Kadmus, Inc.            Topic: N/A

    N/A

    STTR Phase I 2000 Department of Health and Human ServicesNational Institutes of Health
  10. TESTS OF ATTENTION AND MEMORY IN INDIVIDUALS WITH INTELLECTUAL LIMITATIONS

    SBC: PRAXIS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Clinicians and investigators alike rely on tests of attention and memory in a host of fields -- among them psychology, neurology, psychiatry, pediatrics, gerontology, and epidemiology. Yet one segment of the population has been passed by in these assessment efforts: individuals who have limited verbal communication abilities, a group that includes persons with ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
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