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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Gene Therapy to Prevent Esophageal Cancer Associated with Aldehyde Dehydrogenase Deficiency

    SBC: LEXEO Therapeutics LLC            Topic: 400

    AbstractLEXEO TherapeuticsLLCis an early stage biotechnology company focused on using in vivo gene therapy technologies to treat disorders of unmet medical needLEXEO is developing an in vivo gene therapy strategy as a preventative therapy to protect individuals with aldehyde dehydrogenaseALDHdeficiency from the high risk for esophageal cancerAs the next step in the development paththe goal of this ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Composite Integrative Passive Sampler (CIPS)

    SBC: Statera Environmental, Inc.            Topic: NIEHS

    PROJECT SUMMARY Environmental exposure to chemicals has been linked to serious human health problemscontributing to as many asmillion deaths andof all disease burden globally each yearand high economic costs$billion in US and $billion in EUMuch of this exposure comes from contaminated water and in the US alonethere arepublic drinking water systems andmunicipal wastewater systems that discharge to ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Content Validation for a Digital Therapeutic for Adolescent Major Depressive Disorder (MDD)

    SBC: CLICK THERAPEUTICS, INC.            Topic: 104

    PROJECT SUMMARY Major Depressive DisorderMDDis a serioushighly prevalent illness in youthaffecting more thanof adolescents in the United StatesDespite important advances in the treatment of depressionthe majority of adolescents remain untreatedinadequately treated or cannot tolerate an adequate course of treatmentAs MDD continues to pose a significant public health problemwell tolerated new interv ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Three-dimensional organoid culture using the CellRaft microwell technology

    SBC: Cell Microsystems, Inc.            Topic: 400

    Project SummaryOrganoids are minitissue structures that are revolutionizing in vitro studies due to the fact that they arederived from normal or diseased tissues from human donorsinduced pluripotent stem cellsiPSCsand nearlyeverymodelorganismTheuseoforganoidsindiseasemodelinghasbecomeapowerfulmethodtoreplicatepathophysiologyusing straightforwardcellcultureconditionsVirtuallyeverytissuetypenowhasan ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Genetic Modification of the Rabbit for Development of Single Chain Antibodies

    SBC: INGENIOUS TARGETING LABORATORY INC.            Topic: NIAID

    Project Summary With the entry into a new era of gene editingand especially the availability of CRISPR Castoolstargeted genomic modifications of the rabbitOryctolagus cuniculushave now become a scientific realityThe rabbit is the classic and primary antibody producer thanks to its distinct immune biologye ggene conversionIn recent yearsheavy chain only antibodiesHCAbsoriginally discovered in the c ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Quantitative, Image-Based Osteoarthritis Biomarkers Software Resubmission

    SBC: Kitware, Inc.            Topic: NIAMS

    PROJECT SUMMARY Musculoskeletal diseases are common in the United Statesespecially among the elderly and individuals of low socioeconomic statusand they take a large toll on the Nationandapos s overall health statusBone disorders are diagnosed by exploring a patientandapos s medical history and by physical examalongside laboratory testsbonebiopsiesand imaging testsBone imaging tests provide a non ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A compact, modular two-photon fiber-coupled microscope for in vivo all-optical electrophysiology

    SBC: INTELLIGENT IMAGING INNOVATIONS, INC.            Topic: 101

    Good methods to interrogateand ideally perturbneural systems at the network level have been elusive until recentlyThe advent of biochemical breakthroughsnamely neuronally targeted genetically encoded calcium reporterssuch as GCaMPand light activated channelssuch as channelrhodopsinhave enabledall opticalelectrophysiology where experiments can be conducted that involve simultaneousor closely sequen ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Immersive Virtual Reality with Bio-Feedback for Diaphragmatic Breathing Therapy

    SBC: My Music Machines Inc.            Topic: R

    Project Summary The goal of the phase I SBIR project proposed by My Music MachinesIncDBA JamboxxIncis to create an electronic gaming device for diaphragmatic breathingaka deep breathinginstruction for physical therapyusing wearable sensors synched to an immersive virtual realityVRvideo game that can be played on a smartphone device with a VR headsetThe game will guide users through the proper brea ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A facile synthesis of optically pure disubstituted amino acids

    SBC: MONOMERCHEM, inc            Topic: 300

    Project Summary Enantiopuredisubstituted amino acidsEDAAsare valuable fundamental building blocks for medical research in both academics and industryWhen an EDAA is incorporated into the framework of a peptide or a small moleculeboth substituents attached to thecarbon contribute to the moleculeandapos s shapebiological activity and physical propertiesEDAAs can be used to optimize stabilityclogPand ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A New Therapy for Acute Kidney Injury

    SBC: THERASOURCE, LLC            Topic: 400

    PROJECT DESCRIPTIONThe primary objective of this project is to demonstrate the feasibility of developing Cas a novel and effective therapeutic for patients with ischemic acute kidney injuryAKIa significant cause of prolonged hospitalization and mortalityIschemic AKI often complicates hemorrhagic shockseptic shockand surgeryYetdespite it being a frequentlife shorteningand costly complicationno FDA ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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