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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. High throughput screening and drug discovery for antagonists of the Ebola VP40 protein assembly

    SBC: OYAGEN, INC.            Topic: NIAID

    PROJECT SUMMARY This R43 proposal answers the call of the RFA PA-22-176 for assay development and chemical probe screening by addressing the unmet need for development of antiviral treatments for Ebola patients through an innovative high-content small molecule screen for antagonists of the Ebola VP40 matrix protein. There is a need for a fast-acting therapy that is independent of the immune system ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Soft robotic sensor arrays for fast and efficient mapping of cardiac arrhythmias.

    SBC: CONFORM MEDICAL INC            Topic: NHLBI

    Abstract - Conform Medical is applying materials science, soft robotics, and stretchable electronics to revolutionize the mapping and ablation of the aberrant electrical signals underlying arrythmias, starting with ventricular tachycardia (VT), then expanding to other types of cardiac arrythmia such as atrial fibrillation (AFib). Cardiac electrophysiology specialists at hospitals and cardiac cente ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a new class of BLVRB-targeted redox therapeutics in breast cancer

    SBC: BLOOD CELL TECHNOLOGIES LLC            Topic: 102

    SUMMARY Enhanced metabolic and mitochondrial activity inherent in actively proliferating cancer cells generates an excessive amount of reactive oxygen species (ROS), associated with intracellular redox imbalance that impacts cellular viability.To survive chronic oxidative stress, cancer cells evolve to activate scavenging/anti-oxidant enzymes to restore redox balance. This differential activation ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Validating the performance and inclusivity of a novel functionally-informed predictive genetic test method for polygenic disease

    SBC: MARTINGALE LABS, INC.            Topic: 172

    PROJECT SUMMARY We now know that over 90% of causal variants for common diseases, including cardiovascular disease and many cancers, lie in non-coding regions of the genome. Therefore, a complete picture of common disease risk requires analyzing variants across the whole genome, not just the coding genome. Currently available methods to screen for common disease risk focus on monogenic coding vari ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. GMP Production of a Tau Oligomer Inhibitor to Enable Clinical Development forADRD

    SBC: OLIGOMERIX INC            Topic: NIA

    Modified Project Summary/Abstract SectionThis application is for a Phase IIb (R44) renewal of AG066384 titled “GMP production of a tau oligomer inhibitor to enable clinical development for ADRD”. We completed the preclinical work and submitted our IND application to FDA and are ready to begin our first-in-human phase 1a study in January 2023. This application is to perform a study needed to pr ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. A Novel Small Molecule Therapeutic for Acute Graft Versus Host Disease

    SBC: CRESTONE, INC.            Topic: NIAID

    ABSTRACT Allogeneic hematopoietic cell transplantation (allo-HSCT) is an effective therapy for a number of malignant and non- malignant blood and metabolic diseases, but its applicability has been limited by graft-versus-host disease (GvHD). GvHD is responsible for 15-30% of deaths that occur following HSCT and is the main cause of morbidity in up to 50% of recipients. Current prevention and treat ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. A ratcheting pediatric prosthetic finger using advanced rapid manufacturing technology

    SBC: POINT DESIGNS, LLC            Topic: NICHD

    A ratcheting pediatric prosthetic finger using advancedrapid manufacturing technology ABSTRACT The goal of the proposed project is to develop and commercialize a purely mechanical, ratcheting pediatric prosthetic finger – the Point Mini – which 1) has an industry leading strength to weight ratio, 2) can be operated unilaterally (one-handed), 3) offers anatomical rotation and flexion around the ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. EFFICIENT DIFFERENTIATION, SCALE-UP, AND MATURATION OF IPS DERIVED CARDIOMYOCYTES

    SBC: Link Biosystems Inc.            Topic: NHLBI

    Project Summary/Abstract Cell expansion is a critical step for cell therapy, hindered by expensive and complex bioreactor requirements to yield sufficient cell numbers for adequate dosing and requiring expensive regents to enhance functionality for increased clinical success. Similarly, in-vitro models of cardiac disease using induced pluripotent stem cell derived cardiomyocytes (iPS-CM) are of cr ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. PED-PHAM: An Automated and Scalable Spatial Tool That Predicts and Monetizes Health Impacts of the Built, Natural, and Social Environment

    SBC: URBAN DESIGN 4 HEALTH INC            Topic: NHLBI

    The proposed PEDestrian Public Health Assessment Model (PED-PHAM) uses proven Artificial Intelligence (AI) detection methods to derive pedestrian environment features (PEF), such as sidewalks, crosswalks, and lighting, from digital images. It will add these PEFs to Urban Design 4 Health's existing peer reviewed National- PHAM that predicts health outcomes. PED-PHAM will better enable analysts and ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Filtration Media for In-Home PFAS Removal from Drinking Water

    SBC: TDA RESEARCH, INC.            Topic: NIEHS

    Project Summary/Abstract Title Filtration Media for In-Home PFAS Removal from Drinking Water SBIR Phase II Application P.I.: Steven Dietz, TDA Research, Inc. Per- and polyfluoroalkyl substances (PFAS), also commonly known as perfluorinated compounds, are a large family of man-made, globally distributed chemicals that have been used for decades. Perfluorooctanoic acid (PFOA) and perfluorooctane sul ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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