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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Emodin as a complementary dietary therapy to reduce toxicity of 5 fluorouracil

    SBC: AcePre, LLC            Topic: R

    PROJECT SUMMARYfluorouracilFUhas been the first choice chemotherapy drug for colorectal cancerCRCfor many yearshoweverits clinical utility remains hindered by hematopoietic and gastrointestinal toxicities resulting from its non selectivitySide effects include fatigueloss of appetiteand diarrhea among othersall of which can lead to reduced quality of lifeThe economic burden associated with chemothe ...

    STTR Phase I 2018 Department of Health and Human Services
  2. Continuous removal/disposal system for the concurrent sorption and breakdown of contaminants into harmless precipitates

    SBC: Lynntech Inc.            Topic: NIEHS

    PROJECT SUMMARYThere is an ever growing need for useable uncontaminated water in the United States and across the globeThis increasing need includes many uses with the most significant being for potable waterHowevera significant problem is occurring at the confluence of industry and consumer that continues to put access to clean drinkable water at riskindustriesincluding oilmanufacturingagricultur ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Mitigating Injurious Falls in Older Adults Through Non-Injurious Fall and Gait Analysis From Floor Vibrations


    Project Summary and Abstract Falls are the leading cause of death due to injuryThis simple motion is so common thatof community dwelling older adultsandof long term care facilities will experience a fall in the coming yearThe risk of falling substantially increases for those having Alzheimer s disease and related dementiasand those with Parkinson s diseaseThe financial burden is significant with f ...

    STTR Phase I 2018 Department of Health and Human Services
  4. Developing an automated yeast dissection system for aging research

    SBC: Innovative BioChips LLC            Topic: NIA

    PROJECT SUMMARY Developing an Automated Yeast Dissection System for Aging ResearchAging is the single greatest risk factor for diseases that are principal causes of mortalityThe objectives of aging research are to discover key genes and pathways related to aging that may eventually contribute to retardation of aging and a delay in the onset of age associated diseasesThe budding yeast Saccharomyces ...

    STTR Phase II 2018 Department of Health and Human Services

    SBC: INDUS INSTRUMENTS            Topic: NIA

    TITLEImplantable Wireless Telemetric Monitoring Device For Aging Studies In MiceABSTRACTThere has been a dramatic growth in aging research particularly using small animals such as mice to find translatable solutions to improve the health span as we ageWhile undisturbed and non tethered acquisition of physiologic data in awake mice using implantable wireless telemetry technologies reflects the most ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Development of Tetracycline Analogs for Alcohol Use Disorder Treatment

    SBC: South Plains Biotechnology, Inc            Topic: 350

    Project Summary Abstract Statement of the problemOnly three pharmacotherapeutic treatments for Alcohol Use DisorderAUDare FDA approved and none are widely usedandltof AUD patientsor show a strong effect to reduce riskyor dependence based drinking in the long termandltsee sustained decreased drinking outcomesUnfortunatelyapproximatelyof the population suffers from AUD and overof all medical morbidi ...

    STTR Phase I 2018 Department of Health and Human Services
  7. Development and Production of Standardized Reference Diets for Zebrafish Research

    SBC: Meridian Biotech, LLC            Topic: 101

    The over arching goal of this Phase I SBIR proposal is to begin to optimize and implement standard reference diets for the ZebrafishDanio rerioan animal model of critical importance to the understanding of human health and development of vertebrate organismsA key problem in the industry is that standardized diets or feed management strategies have not been developed for Danio rerioThese diets are ...

    STTR Phase I 2018 Department of Health and Human Services
  8. Dose-ranging safety and efficacy studies to advance novel mechanism-of-action drug candidates to reverse age-related muscle degeneration


    In the USthe number of individuals agedand older will increase byover the next decadeConcurrentlyMedicare costs are expected to double to treat chronic diseases that will plague this increasing number of older adultsOne of the most wide spread chronic diseases that affects older adults is sarcopeniawhich is observed inof adults overyears of age andof adults overyears of ageThis disease is characte ...

    STTR Phase I 2018 Department of Health and Human Services
  9. Innovative Delivery of siRNA across the Blood Brain Barrier

    SBC: Fannin Partners, LLC            Topic: NIA

    Project Summary Drug delivery across the blood brain barrier is a significant challenge in developing successful therapeutics for brain malignanciesDespite significant advances in developing small moleculespeptidesand nucleic acid treatment optionssuccessful delivery of these molecules to the brain diminishes their promiseWe propose a novel approach of delivering small interfering RNAsiRNAacross t ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Novel Use of Volatile Anesthetics as Topical Treatment for Painful Inflammatory Conditions: Interactions with Integrins and In Vivo Anti-inflammatory Effects.

    SBC: Vapogenix, Inc.            Topic: NIAMS

    Summary Abstract Problem of painful inflammatory diseasesPersistent or inappropriate inflammation underlies a broad range of painful diseases including musculoskeletal conditionswounds and burnsMuch of the pain associated with these diseases is due to the release of nociceptive mediators from leukocytes at the site of inflammationThough treatments such as NSAIDsNon Steroidal Anti inflammatory Drug ...

    SBIR Phase I 2018 Department of Health and Human Services

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