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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Extending clinical trial in AD patients from 1 to 3 months

    SBC: PAIN THERAPEUTICS, INC.            Topic: NIA

    Project Summary Abstract PTIis a novel small molecule AD therapeutic candidate with a novel target and mechanism of actionPTIbinds and reverses an altered conformation of the scaffolding protein filamin AFLNAto prevent Aandapos s tight binding to and toxic signaling via thenicotinic acetylcholine receptornAChRas well as Aandapos s aberrant activation of toll like receptorTLRHenceby restoring FLNAa ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Preclinical evaluation of a novel small molecule STAT inhibitor

    SBC: Fannin Partners, LLC            Topic: NIAID

    Project Summary Problem statementAsthma is one of the most common and burdensome of all chronic inflammatory diseasescausing almost lifelong respiratory symptoms to various degrees through a patient s life due to severe airway inflammationairway obstructionand triggered hyper responsivenessAlmostof these individuals experience very severecomplexand heterogeneous disease symptoms that remain intrac ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Development of a Low-Profile Dual Hormone Patch Pump with Novel Occlusion Sensor

    SBC: Sfc Fluidics, Inc.            Topic: 200

    Development of a Low Profile Dual Hormone Patch Pumpwith Novel Occlusion Sensor Project SummaryThe Specific Aim of this project is to develop a discretelow profiledual hormone drug delivery system using SFC Fluidicsenabling microfluidic technologiesA DualPumpwill be developed in which one proprietary ePumpbody will independently and accurately deliver both insulin and glucagon from two separate re ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. Rapid Test Kit for Measurement of Urinary Iodine

    SBC: Lynntech Inc.            Topic: NICHD

    Iodine is an essential micronutrient and an integral component of thyroid hormonesIodine is obtained through the diet and is mainly absorbed by the gastrointestinal tract as the inorganic anioniodideAn accurate assessment of population iodine status is necessary to inform public health policies and clinical research on iodine nutritionUrinary iodine concentrationUICdirectly reflects dietary iodine ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Multicolor Photoacoustic Malaria Detector

    SBC: CytoAstra, LLC            Topic: NIAID

    Summary Malaria continues to be a global health prioritywith almost half of the world s populationbillionat risk and arounddeaths each yearOvertreatment is caused by lack of diagnosis and contributes to resistancea huge threat as illustrated by artemisinin resistance in Southeast AsiaLittle progress has been made in the novel methods to diagnose malarialet alone in reliably identifying asymptomati ...

    STTR Phase I 2018 Department of Health and Human Services
  6. Non-Metal PN Scavenger/Decomposition Catalysts for Treatment of Migraine


    Project SummaryAbstract The World Health Organization ranks migraine as therd most prevalent disease worldwide andth most disablingth most in womenmaking it the most common neurological disorderOne of the primary reasons for the disabling nature of migraine is the poor efficacy of currently available therapeuticsLess thanof patients achieve complete relief with acute agents such as triptans and on ...

    STTR Phase I 2018 Department of Health and Human Services
  7. A cloud-based system for scalable, privacy-preserving, and interactive immune repertoire analysis in vaccination and infection

    SBC: ImmuDX LLC            Topic: NIAID

    PROJECT SUMMARY We propose to build a cloud based integrated solution for scalablecustomizableprivacy preservingand interactive antibody repertoire analysisImmune repertoire sequencingIR seqhas become a useful tool in both basic research and clinical settingsAs the heart of the adaptive immunity to infection and many vaccinesthe abundance and diversity composition of the B cell receptorBCRand its ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. DMSO-free Cryopreservation of Bone Marrow-derived Stem Cells


    ABSTRACT Stem cell transplantation in the form of bone marrowperipheral blood or cord blood derived cells is commonly performed for reconstitution of the hematopoietic system of patients suffering from cancers and non malignant diseasesCurrent practice for cryopreservation of hematopoietic and mesenchymal stem cells is to employ the cell permeating cryoprotectant dimethylsulfoxideoften with an add ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Automation of bioengineered epithelial construct cryopreservation


    ABSTRACT BSTRACT In an effort to reduce the use of animals for toxicity testingcompanies have developed bioengineered in vitro skin models to replace the Draize skin irritation testThe development of tissue models has been further pushed by the European Union that prohibited the use of animals infor collecting toxicological data on cosmetic ingredientsSupply of bioengineered tissues is a significa ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Universal Medical Device Identifier

    SBC: BridgeSource Medical, Corp.            Topic: NIA

    Abstract Cardiovascular Implantable Electronic DevicesCIEDslike a Permanent Pacemaker or Implantable Defibrillator are implanted in overmillion Americanswith the average age of implantation in thesyears oldandyears oldWhen a patient presents to the Emergency DepartmentEDwith an unknown CIEDreprogramming of the device is often necessary for their treatmentEvery patient should know their device type ...

    SBIR Phase I 2018 Department of Health and Human Services

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