Award Data

This contract is to provide proof of concept studies for the development of a monoclonal antibody to combat P. falciparum malaria.

Membrane proteins play a fundamental and critical role in cellular processes. Their direct link to human disease as well as their key role in signal transduction, has made many membrane proteins the foremost targets for chemotherapeutic intervention with more than 50% of all drugs designed to modulate the activity of this class of proteins. Despite this central role in human health, the biochemica ...

Project Abstract Millions of patients with Alzheimer’s disease (AD) suffer from sleep disturbances that significantly degrade their quality of life and amplifies the heavy emotional burden on caregivers. Restless Legs Syndrome (RLS) is likely a factor for the sleep disturbance in these patients, however, RLS is currently difficult to diagnose, particularly in patients with AD. The diagnosis is m ...

ABSTRACT The aim of this project is to conduct a pivotal clinical trial of Sanaria’s Plasmodium falciparum (Pf) whole sporozoite (SPZ) vaccine, Sanaria® PfSPZ Vaccine, to support licensure for travelers. This is an important step toward licensure for the underserved populations who need it most, especially in Africa. The urgency of developing a malaria vaccine has been highlighted by COVID-19. ...

Abstract Ulcerative colitis and Crohn’s disease are major forms of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation and gut microbiota dysbiosis. IBD has been associated with poor quality of life and often results in complications requiring hospitalizations and surgical procedures that causes significant morbidity and financial losses in the US. In past ...

Abstract Hazardous material releases pose a serious threat to our communities. In 2018, the Stakeholder Preparedness Review (SPR) found that 50% of states and territories identified chemical and radiological hazardous material releases, the most frequently cited ‘technological hazard’ was a troubling concern (FEMA, 2019). In 2019, the Department of Transportation reported an all-time high 22,7 ...

PROJECT SUMMARY/ABSTRACT Severe kidney disease accounts for 7% of all Medicare and Medicaid costs. The most cost-effective way to perform dialysis uses an arteriovenous fistula to connect to dialysis machines, but fistula use is limited by the malfunctions immediately following creation (maturation failure), which can render up to 70% of all created fistulas unusable. Ultrasound monitoring of the ...

Summary Despite large investments in nucleic acid technology, the ability to sequence large numbers of full-length individual RNAs, from complex samples, with highest accuracy, has remained out of reach. Pheno introduces an advance for large scale Next Generation DNA Sequencing (NGS) sequencing of effectively unlimited numbers of individual RNA molecules from heterogeneous mixtures. We seek to pro ...

ABSTRACTDelayed identification of infant head malformation is causing unnecessary medical complications and societal costs. A critical challenge in the early detection is the absence of tools available to pediatric offices to perform quantitative head shape assessment during well-child visits. Delays in diagnosis limit the opportunity for early, less invasive and effective treatment options. In th ...

Project abstract/summary In the proposed research, GlycoT will employ its proprietary chemoenzymatic glycan-remodeling platform to establish a facile, robust, and scalable site-specific antibody conjugation technology. Conjugation of various functional molecules to antibodies are frequently used for a wide variety of applications within the life science sectors, such as fluorescent labeled antibod ...